Results 61 to 70 of about 90,366 (260)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
آداب الكوفةSince its emergence in 1970 up to the present time with its different versions, metrical theory has been used and applied to different texts in different languages.
ايثار جميل +1 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
International Journal of Turbomachinery, Propulsion and PowerStability theory offers a practical method on parametric studies that encompass scales in the boundary layer typically not captured in Large Eddy (LES) or Reynolds-Averaged Navier–Stokes (RANS) simulations.
Alice Fischer, Frank Eulitz
doaj +1 more source
Adaptive Controller Design for Faulty UAVs via Quantum Information Technology
International Journal of Advanced Robotic Systems, 2012 In this paper, an adaptive controller is designed for a UAV flight control system against faults and parametric uncertainties based on quantum information technology and the Popov hyperstability theory.
Fuyang Chen, Rui Hou, Gang Tao
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
A systematic analysis of parametric instabilities in nonlinear parabolic multimode fibers
APL Photonics, 2019 We provide a systematic analysis of geometric parametric instabilities in nonlinear graded-index multimode fibers. Our approach implicitly accounts for self-focusing effects and considers dispersion processes to all orders. It is shown that the resulting
H. E. Lopez-Aviles +6 more
doaj +1 more source