Results 51 to 60 of about 24,151,088 (246)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Non-Parametric Anthropometric Graph Convolutional Network for Virtual Mannequin Reconstruction

IEEE Access, 2020
In this paper, we present a novel non-parametric method for precisely reconstructing a three dimensional (3D) virtual mannequin from anthropometric measurements and mask image(s) based on Graph Convolution Network (GCN).
Haoyang Xie, Yueqi Zhong, Zhicai Yu, Azmat Hussain   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Simulation model of a queuing system in the service of state registration, cadastre and cartography [PDF]

E3S Web of Conferences
The results of formalizing the queuing system in the public not-for-profit company Roskadastr have been presented in this study. For this purpose, all objects involved in processing applications have been identified.
Altunina Yulia, Korotun Olga, Polevshchikov Ivan   +2 more
doaj   +1 more source

Finite Element Analysis based on A Parametric Model by Approximating Point Clouds

Remote Sensing, 2020
Simplified models are widely applied in finite element computations regarding mechanical and structural problems. However, the simplified model sometimes causes many deviations in the finite element analysis (FEA) of structures, especially in the non ...
Wei Xu, Ingo Neumann
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Parametric Reconstruction Method of Wheat Leaf Curved Surface Based on Three-Dimensional Point Cloud

智慧农业
[Objective]Plant leaf shape is an important part of plant architectural model. Establishment of a three-dimensional structural model of leaves may assist simulating and analyzing plant growth.
ZHU Shunyao, QU Hongjun, XIA Qian, GUO Wei, GUO Ya   +4 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Automatic Transition Prediction for Three-Dimensional Configurations with Focus on Industrial Application [PDF]

, 2010
A computational method to predict transition lines for general three dimensional configurations is presented. The method consists of a coupled program system including a 3D Navier-Stokes solver, a transition prediction module, a boundary-layer code and a
Krumbein, Andreas, Andreas Krumbein, Normann Krimmelbein, Krimmelbein, Normann   +3 more
core   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source