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Lost in Cognition: Paraneoplastic Rhombencephalitis With Anti-Ri/Antineuronal Nuclear Antibody Type 2 (ANNA-2) Antibodies Presenting as Rapid-Onset Cognitive Decline and Ophthalmoplegia-Ataxia With Reversible Brainstem Lesion. [PDF]
CureusAwada Z, Alboudi A, Jabeen I, Yu E.
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Paraneoplastic Syndromes Involving the Nervous System
New England Journal of Medicine, 2003Paraneoplastic neurologic syndromes are incited by a tumor outside the nervous system that produces a characteristic antigen of the nervous system. An immune response against the ectopic tumor antigen not only damages nerve tissue but also inhibits growth of the tumor.
Robert B, Darnell, Jerome B, Posner
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PARANEOPLASTIC SYNDROMES AFFECTING THE CENTRAL NERVOUS SYSTEM
Annual Review of Medicine, 1997▪ Abstract  Paraneoplastic syndromes affecting the nervous system are rare neurologic syndromes caused by cancer but not ascribable to metastases. Any portion of the nervous system may be involved in a paraneoplastic syndrome. The pathogenesis of these disorders appears to be an immune reaction against antigens shared by the cancer and the nervous ...
J B, Posner, J O, Dalmau
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Paraneoplastic Syndromes Affecting the Nervous System
Seminars in Oncology, 2006The paraneoplastic neurologic disorders (PND) are a diverse group of diseases characterized by the presence of neurologic dysfunction in the setting of a remote cancer. PND can affect almost any part of the nervous system, and are most commonly associated with lung cancer (small cell) and gynecologic tumors. Laboratory studies have demonstrated that an
Robert B, Darnell, Jerome B, Posner
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Paraneoplastic Syndromes of the Nervous System
cclm, 2000Abstract Paraneoplastic syndromes affecting the nervous system are unique among immune-mediated disorders in that the trigger of the immune response is known: tumor expression of proteins normally restricted to neurons (or other immunoprivileged sites, such as testis) but ectopically expressed in some cancers results in an immunological ...
J B, Posner, J O, Dalmau
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Paraneoplastic nervous system syndromes
Current Opinion in Oncology, 1996Recent progress in the understanding of the paraneoplastic neurologic syndromes has included further deliniation of the clinical syndromes and their treatment, attempts at standardization of the diagnostic nomenclature, investigations of pathogenetic mechanisms, and molecular characterization of the paraneoplastic antigens with implications as to their
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Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes
Neurology, 1990We measured the activity of 2 highly specific autoantibodies (anti-Yo associated with paraneoplastic cerebellar degeneration and anti-Hu associated with paraneoplastic sensory neuronopathy-encephalomyelitis) in simultaneously procured samples of serum and CSF of 18 patients.
H F, Furneaux, L, Reich, J B, Posner
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Paraneoplastic Syndromes of the Nervous System
2003In patients with cancer the development of neurological symptoms usually represents metastatic involvement of the nervous system, or complications secondary to coagulopathy, infection, metabolic and nutritional deficits, and toxic effects of cancer therapy (1).
Myrna R. Rosenfeld, Josep Dalmau
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[Paraneoplastic syndromes of the central nervous system].
La Clinica terapeutica, 2000Paraneoplastic syndromes of central nervous system are rare neurologic syndromes caused by cancer but not secondary to metastases. The physiopathologic mechanisms underlying these syndromes are still under debate. We report the biological and clinical features of the most frequent paraneoplastic syndromes involving the central nervous system.
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