Results 101 to 110 of about 110,945 (357)

Surgery for progressive Pott's paraplegia (tuberculous paraplegia) [PDF]

Spinal Cord, 1991
This is a study of 20 patients who had surgical intervention for Pott's paraplegia at the Hacettepe University Neurosurgery Department, Ankara. All patients were admitted with progressive paraparesis. Eleven patients had vertebrectomies, 5 laminectomies and in 4 patients costo-transversectomies were performed.
Aykut Erbengi, B Açikgöz, Deniz Belen, Osman Ekin Özcan, Tunçalp Özgen   +4 more
openaire   +3 more sources

Complicated spastic paraplegia in patients with AP5Z1 mutations (SPG48)

Neurology: Genetics, 2016
Objective: Biallelic mutations in the AP5Z1 gene encoding the AP-5 ζ subunit have been described in a small number of patients with hereditary spastic paraplegia (HSP) (SPG48); we sought to define genotype–phenotype correlations in patients with ...
Jennifer Hirst, M. Madeo, K. Smets, J. Edgar, L. Schols, Jun Li, Anna Yarrow, T. Deconinck, J. Baets, E. V. van Aken, J. D. De Bleecker, Manuel B. Datiles III, R. Roda, J. Liepert, S. Züchner, C. Mariotti, P. de Jonghe, C. Blackstone, M. Kruer   +18 more
semanticscholar   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Hereditary spastic paraplegia: Novel insights into the pathogenesis and management

SAGE Open Medicine
Hereditary spastic paraplegia is a genetically heterogeneous neurodegenerative disorder characterised primarily by muscle stiffness in the lower limbs. Neurodegenerative disorders are conditions that result from cellular and metabolic abnormalities, many
Wireko Andrew Awuah, Joecelyn Kirani Tan, Anastasiia D Shkodina, Tomas Ferreira, Favour Tope Adebusoye, Adele Mazzoleni, Jack Wellington, Lian David, Ellie Chilcott, Helen Huang, Toufik Abdul-Rahman, Vallabh Shet, Oday Atallah, Jacob Kalmanovich, Riaz Jiffry, Divine Elizabeth Madhu, Kateryna Sikora, Oleksii Kmyta, Mykhailo Yu Delva   +18 more
doaj   +1 more source

Survey of the needs of patients with spinal cord injury: impact and priority for improvement in hand function in tetraplegics\ud [PDF]

, 2004
Objective: To investigate the impact of upper extremity deficit in subjects with tetraplegia.\ud \ud Setting: The United Kingdom and The Netherlands.\ud \ud Study design: Survey among the members of the Dutch and UK Spinal Cord Injury (SCI) Associations.\
BR Johnstone, C Long, C Murphy, CL Mc Dowell, E Moberg, EG Widerstrom-Noga, EM Andresen, G Bedbrook, GJ Snoek, GW Torrance, JF Ditunno, JH van Tuijl, L Harvey, LA Harvey, LA May, M Curtin, M Dijkers, M Johannesson, M Ryan, MJ De Vivo, MW Keith, MW Keith, P Kersten, PH Gorman, PH Peckham, R Triolo, R Waters, RF Pangalila, RJ Cox, RM Andersen, RW Hanson   +30 more
core   +2 more sources

Spastic Ataxia Composite (SPAXCOM): A Scale to Evaluate the Progression of Subjects with Spasticity and Ataxia

Movement Disorders, EarlyView.
Abstract Background Current clinical scales that track disease progression are more tailored to spasticity or ataxia, with limited sensitivity to change. Objectives The aim was to develop a sensitive and valid scale specifically geared towards optimized sensitivity to change and adapted to patients presenting with both spasticity and ataxia.
Cécile Di Folco, Charlotte Dubec‐Fleury, Andreas Traschütz, Christoph Kessler, Selina Reich, Cynthia Gagnon, Isabelle Lessard, Xavier Rodrigue, Sirio Cocozza, Sara Satolli, Filippo M. Santorelli, Alexandra Durr, Anna Heinzmann, Bart P. van de Warrenburg, Ilse H.J. Willemse, A. Nazli Başak, Atay Vural, Bernard Brais, Stephan Klebe, Rita Horvath, PROSPAX Consortium, May Yung Tiet, Heather Biggs, Emma Harrison, Dagmar Timmann, Nicole Jeschonneck, Paulina Cunha, Hortense Hurmic, Lucie Pierron, Giulia Coarelli, Claire Ewenczyk, Ivana Ricca, Melissa Barghigiani, Nazan Akkaya, Özgür Öztop Çakmak, Rebecca Schüle, Matthis Synofzik, Sophie Tezenas du Montcel   +37 more
wiley   +1 more source

Abnormal Connectivity of the Head Neural Integrator in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia is characterized by abnormal neck and head movements, possibly related to a dysfunction of the interstitial nucleus of Cajal (INC) and the head neural integrator, a system responsible for the control of head and eye movements.
Giuseppe A. Zito, Emmanuel Roze, Clément Tarrano, Salim Ouarab, Prasanthi Jegatheesan, Asya Ekmen, Benoît Béranger, Romain Valabregue, Cécile Hubsch, Sophie Sangla, Cécilia Bonnet, Cécile Delorme, Aurélie Méneret, Bertrand Degos, Floriane Bouquet, Marion Apoil Brissard, Marie Vidailhet, Dominique Hasboun, Pierre Pouget, Yulia Worbe, Cécile Gallea   +20 more
wiley   +1 more source

A pseudo‐homozygous missense variant and Alu‐mediated exon 5 deletion in FARS2 causing spastic paraplegia 77

Annals of Clinical and Translational Neurology
FARS2‐associated hereditary spastic paraplegia, later onset spastic paraplegia type 77, is a rarely neurodegenerative disease. Here, we reported two affected siblings in an autosomal recessive spastic paraplegia family with a pseudo‐homozygous missense ...
Shu‐Huai Lin, Jun‐Hao Xie, Jun‐Yi Jiang, Xin‐Yu Yan, Chao‐Yin Hong, Wan‐Jin Chen, Ning Wang, Xiang Lin   +7 more
doaj   +1 more source

Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute non compressive nucleus pulposus extrusion [PDF]

, 2016
OBJECTIVE To compare clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with presumptive acute noncompressive nucleus pulposus extrusion (ANNPE). DESIGN Retrospective study. ANIMALS 51 dogs with ischemic myelopathy and
De Decker, S, Drees, R, Fenn, J T, Volk, H A   +3 more
core   +2 more sources

Feedback control of unsupported standing in paraplegia. Part I: optimal control approach [PDF]

, 1997
This is the first of a pair of papers which describe an investigation into the feasibility of providing artificial balance to paraplegics using electrical stimulation of the paralyzed muscles. By bracing the body above the shanks, only stimulation of the
Donaldson, N., Hunt, K.J., Munih, M.
core