Results 41 to 50 of about 24,448 (314)

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

PLoS Neglected Tropical Diseases, 2013
Background/objectivesHuman leishmaniases are parasitic diseases causing severe morbidity and mortality. No vaccine is available and numerous factors limit the use of current therapies.
Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, Pierre-Henri Commere, Hélène Munier-Lehmann, Gerald F Späth, Spencer L Shorte, Geneviève Milon, Eric Prina   +10 more
doaj   +1 more source

Dendritic cell-mediated vaccination relies on interleukin-4 receptor signaling to avoid tissue damage after Leishmania major infection of BALB/c mice. [PDF]

PLoS Neglected Tropical Diseases, 2012
Prevention of tissue damages at the site of Leishmania major inoculation can be achieved if the BALB/c mice are systemically given L. major antigen (LmAg)-loaded bone marrow-derived dendritic cells (DC) that had been exposed to CpG-containing ...
Anita Masic, Ramona Hurdayal, Natalie E Nieuwenhuizen, Frank Brombacher, Heidrun Moll   +4 more
doaj   +1 more source

Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii [PDF]

, 2018
Sulfur-containing amino acids play essential roles in many organisms. The protozoan parasite Toxoplasma gondii includes the genes for cystathionine β-synthase and cystathionine γ-lyase (TgCGL), as well as for cysteine synthase, which are crucial enzymes ...
Astegno, A., Dominici, P, Fruncillo, S, Janson, G, Maresi, E, Paiardini, A, Vallone, R   +6 more
core   +2 more sources

Identification and characterization of the Plasmodium vivax thrombospondin-related apical merozoite protein

Malaria Journal, 2010
Background Malaria caused by Plasmodium vivax is a major public health problem worldwide that affects 70-80 million people in the Middle East, Asia, Western Pacific, South America and the Caribbean.
Villarreal-Gonzalez Silvana, Moreno-Perez Darwin A, Angel Diana I, Mongui Alvaro, Almonacid Hannia, Vanegas Magnolia, Patarroyo Manuel A   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Toxoplasma effectors targeting host signaling and transcription [PDF]

, 2017
Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during
Ajioka JA, Andrisani OM, Carruthers VB, Ceravolo IP, Deckert-Schlüter M, Dubey JP, Frenkel JK, Frenkel JK, Gazzinelli R, Gazzinelli RT, Gazzinelli RT, Goebel S, Honoré S, Levine ND, Luder CG, McCabe RE, McLeod R, McLeod R, Morisaki JH, Nash PB, Pfaff AW, Scharton-Kersten TM, Were SR, Yap GS   +23 more
core   +2 more sources

Development and Preliminary In Vivo Study of 3D‐Printed Bioactive Glass Scaffolds with Trabecular Architecture

Advanced Engineering Materials, EarlyView.
This study reports the fabrication of trabecular bioactive glass scaffolds (composition “1d”: 46.1SiO2‐28.7CaO‐8.8MgO‐6.2P2O5‐5.7CaF2‐4.5Na2O wt%) through vat photopolymerization and the relevant results from mechanical testing and in vivo implantation procedures in rabbit femora, showing great promise for bone tissue engineering applications.
Dilshat Tulyaganov, Roberta Gabrieli, Avzal Akbarov, Nigora Nigmatova, Bekhzod Khabilov, Alessandro Schiavi, Martin Schwentenwein, Enrica Verné, Francesco Baino   +8 more
wiley   +1 more source

Epizoic acoelomorph flatworms impair zooplankton feeding by the scleractinian coral Galaxea fascicularis

Biology Open, 2012
Summary Many scleractinian coral species host epizoic acoelomorph flatworms, both in aquaculture and in situ. These symbiotic flatworms may impair coral growth and health through light-shading, mucus removal and disruption of heterotrophic feeding.
Tim Wijgerde, Pauke Schots, Eline Van Onselen, Max Janse, Eric Karruppannan, Johan A. J. Verreth, Ronald Osinga   +6 more
doaj   +1 more source

Engineering Porous Hollow Metal‐Poly(Heptazine Imide) Spheres: An Optimized Synthetic Strategy for Controlling Surface, Morphology, and Properties

Advanced Functional Materials, EarlyView.
Hollow poly(heptazine imide) spheres are prepared through a novel approach that integrates hard templating with ionothermal synthesis. This method enables precise control over surface area, pore volume, hydrophilicity, light absorption, band position, and metal composition. These tunable properties facilitate the customized design of semiconductors for
Lingli Ni, Erik Troschke, Henrik Vorwerk, Shiva Shahbazi Avarvand, Andreas Stihl, Nadzeya Brezhneva, Marius Hermesdorf, Desirée Leistenschneider, Felix H. Schacher, Jacob Schneidewind, Martin Oschatz   +10 more
wiley   +1 more source