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Frontiers in Immunology, 2018 Resource availability is a key environmental constraint affecting the ecology and evolution of species. Resources have strong effects on disease resistance, but they can also affect the other main parasite defense strategy, tolerance. A small but growing
Sarah A. Budischak +2 more
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Frontiers in Cellular and Infection Microbiology, 2021 Protozoans of the genus Leishmania are the causative agents of an important neglected tropical disease referred to as leishmaniasis. During their lifecycle, the parasites can colonize the alimentary tract of the sand fly vector and the parasitophorous ...
Anita Leocadio Freitas-Mesquita +3 more
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Frontiers in Drug Discovery, 2023 Introduction: Suramin is one of the pharmacopeia’s most promiscuous drugs. Originally developed for African trypanosomiasis, suramin was also used for onchocerciasis and it has been proposed as an anticancer agent, antiviral drug, therapy for arthritis ...
Dennis A. Hauser +3 more
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Combination With Tomatidine Improves the Potency of Posaconazole Against Trypanosoma cruzi
Frontiers in Cellular and Infection Microbiology, 2021 Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T.
Marianne Rocha-Hasler +18 more
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17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death
Microorganisms, 2021 The heat shock protein 90 (Hsp90) is thought to be an excellent drug target against parasitic diseases. The leishmanicidal effect of an Hsp90 inhibitor, 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), was previously demonstrated in both in vitro and ...
Antonio Luis de O. A. Petersen +7 more
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Parasites & Vectors, 2021 Background Merozoite surface protein 1 (MSP1) plays an essential role in erythrocyte invasion by malaria parasites. The C-terminal 19-kDa region of MSP1 has long been considered one of the major candidate antigens for a malaria blood-stage vaccine ...
Qinwen Xu +11 more
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Frontiers in Genetics, 2021 Plasmodium falciparum surface-related antigen (SRA) is located on the surfaces of gametocyte and merozoite and has the structural and functional characteristics of potential targets for multistage vaccine development.
Bo Yang +15 more
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microRNAs in parasites and parasite infection [PDF]
RNA Biology, 2013 miRNAs, a subclass of small regulatory RNAs, are present from ancient unicellular protozoans to parasitic helminths and parasitic arthropods. The miRNA-silencing mechanism appears, however, to be absent in a number of protozoan parasites. Protozoan miRNAs and components of their silencing machinery possess features different from other eukaryotes ...
Yadong, Zheng +2 more
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Parasites & Vectors, 2021 Background Gastrointestinal nematode (GIN) epidemiology is changing in many regions of the world due to factors such as global warming and emerging anthelmintic resistance.
Tong Wang +10 more
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Prevalence of Gastrointestinal Helminthiasis in Beef Cattle During Dry Season in Bangkalan Regency, Madura, Indonesia [PDF]
E3S Web of Conferences, 2023 This study aims to observe and determine the risk factor of gastrointestinal helminthiasis among Madura beef cattle and Madura-Limousine crossbreed cattle in Bangkalan Regency during dry season.
Zalizar Lili +4 more
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