Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2017 Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide ...
Reimar Krieg +19 more
doaj +14 more sources
Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review [PDF]
Marine Drugs, 2023 Parasitic diseases, especially those caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, and lymphatic filariasis, are the cause of millions of morbidities and deaths every
Maria João Rodrigues +4 more
doaj +4 more sources
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases [PDF]
Molecules, 2018 Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against T. cruzi.
Ouldouz Ghashghaei +8 more
doaj +4 more sources
Phosphonium lipocations as antiparasitic agents. [PDF]
Bioorg Med Chem Lett, 2012 Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P.
Long TE +5 more
europepmc +6 more sources
Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents [PDF]
Molecules, 2021 The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences.
Paolo Saul Coghi +4 more
doaj +2 more sources
Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents [PDF]
Marine Drugs, 2023 Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance.
Ricardo Ribeiro +4 more
doaj +2 more sources
Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents [PDF]
Molecules, 2020 Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic
Daiana K. Deda +4 more
doaj +2 more sources
Antiplasmodial Activity of p-Substituted Benzyl Thiazinoquinone Derivatives and Their Potential against Parasitic Infections [PDF]
Molecules, 2020 Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria control ...
Marcello Casertano +6 more
doaj +4 more sources
Antiparasitic Agent Atovaquone [PDF]
Antimicrobial Agents and Chemotherapy, 2002 Atovaquone is a unique naphthoquinone with broad-spectrum antiprotozoal activity. It is effective for the treatment and prevention of Pneumocystis carinii pneumonia (PCP), it is effective in combination with proguanil for the treatment and prevention of malaria, and it is effective in combination with azithromycin for the treatment of babesiosis. There
Aaron L, Baggish, David R, Hill
+6 more sources
Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents [PDF]
Pharmaceuticals, 2016 A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b.
Jean J. Vanden Eynde +7 more
doaj +2 more sources