Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2017 Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide ...
Reimar Krieg +19 more
doaj +11 more sources
Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review [PDF]
Marine Drugs, 2023 Parasitic diseases, especially those caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, and lymphatic filariasis, are the cause of millions of morbidities and deaths every
Maria João Rodrigues +4 more
doaj +4 more sources
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases [PDF]
Molecules, 2018 Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against T. cruzi.
Ouldouz Ghashghaei +8 more
doaj +6 more sources
Therapeutic Potential of Marine-Derived Cyclic Peptides as Antiparasitic Agents [PDF]
Marine Drugs, 2023 Parasitic diseases still compromise human health. Some of the currently available therapeutic drugs have limitations considering their adverse effects, questionable efficacy, and long treatment, which have encouraged drug resistance.
Ricardo Ribeiro +4 more
doaj +3 more sources
Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents [PDF]
Pharmaceuticals, 2016 A series of 15 alkanediamide-linked bisbenzamidines and related analogs was synthesized and tested in vitro against two Trypanosoma brucei (T.b.) subspecies: T.b. brucei and T.b.
Jean J. Vanden Eynde +7 more
doaj +4 more sources
Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents [PDF]
Molecules, 2020 Porphyrins and analogous macrocycles exhibit interesting photochemical, catalytic, and luminescence properties demonstrating high potential in the treatment of several diseases. Among them can be highlighted the possibility of application in photodynamic
Daiana K. Deda +4 more
doaj +4 more sources
Phosphonium lipocations as antiparasitic agents [PDF]
Bioorganic and Medicinal Chemistry Letters, 2012 Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P.
Philip Rosenthal +2 more
exaly +5 more sources
Organoboron Compounds: Effective Antibacterial and Antiparasitic Agents [PDF]
Molecules, 2021 The unique electron deficiency and coordination property of boron led to a wide range of applications in chemistry, energy research, materials science and the life sciences.
Paolo Saul Coghi +4 more
doaj +2 more sources
Author Correction: Arylmethylamino steroids as antiparasitic agents [PDF]
Nature Communications, 2019 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Reimar Krieg +19 more
doaj +2 more sources
Sustainable Antiparasitic Agents from an Agro-Industrial Waste: Mitochondria-Targeting Cashew Nutshell Liquid-Derived Phosphonium and Ammonium Salts. [PDF]
J Med ChemInnovative, sustainable therapies are urgently needed for neglected vector-borne parasitic diseases. In this study, we leveraged cashew nutshell liquid (CNSL), an agro-industrial byproduct, to develop biobased phosphonium and ammonium salts (5–25 ...
Martinengo B +24 more
europepmc +5 more sources