Results 31 to 40 of about 292,447 (266)

ANALYSIS OF CIRCULATING STRAINS, CAUSING INVASIVE LISTERIOSIS IN BULGARIA FOR TEN YEARS, 2010-2019

Problems of Infectious and Parasitic Diseases, 2020
Listeriosis is a zoonosis with multiple mechanisms of infection and multiple organ symptoms, severe course and high lethality. An increasing incidence of listeriosis has been reported in several European countries in recent years.
Evgeniya Taseva, Iva Christova, Elitsa Panayotova, Iva Trifonova, Teodora Gladnishka, Vladislava Ivanova   +5 more
doaj   +1 more source

Serodiagnosis of parasitic diseases [PDF]

Clinical Microbiology Reviews, 1991
In this review on serodiagnosis of parasitic diseases, antibody detection, antigen detection, use of monoclonal antibodies in parasitic serodiagnosis, molecular biological technology, and skin tests are discussed. The focus at the Centers for Disease Control on developing improved antigens, a truly quantitative FAST-enzyme-linked immunosorbent assay ...
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

IMMUNOBLOT REACTIVITIES OF DIFFERENT LYME DISEASE SPECIFIC ANTIGENS TO ANTI-BORRELIA BURGDORFERI IgG ANTIBODIES

Problems of Infectious and Parasitic Diseases
Background: Lyme disease is a vector-borne disease with increasing incidences in last years. It is the most common tick-borne infection in Bulgaria, caused by Borrelia burgdorferi sensu lato (Bbsl) complex after a bite from Ixodes ricinus tick.
Teodora Gladnishka, Iva Trifonova, Kim Ngoc, Vladislava Ivanova, Elitsa Panayotova, Evgenia Taseva, Iva Christova   +6 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain

Frontiers in Immunology, 2019
Toxoplasma gondii causes infections in a wide range of intermediate hosts and remains a threatening disease worldwide because of the lack of effective drugs and vaccines.
Bin Zheng, Bin Zheng, Di Lou, Di Lou, Jianzu Ding, Jianzu Ding, Xunhui Zhuo, Xunhui Zhuo, Haojie Ding, Haojie Ding, Qingming Kong, Qingming Kong, Shaohong Lu, Shaohong Lu   +13 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Molecular characterization and B-cell epitope analysis of the TSP11 gene in Echinococcus infection strains from Yunnan Province

Parasitology
This study investigates the molecular intricacies of the transmembrane protein TSP11 gene in Echinococcus strains isolated from livestock and patients in Yunnan Province afflicted with Echinococcus granulosus (E. granulosus) between 2016 and 2020.
Qian Xu, Zhengqing Wang, Jinrong Zi, Xuan Cai, Fangwei Wu, Benfu Li, Jia Peng, Jianxiong Li, Xinliu Yan, Ying Dong, Yaming Yang   +10 more
doaj   +1 more source

Immune responses result in misdiagnosis of Schistosoma japonicum by immunodiagnosis kits in egg-positive patients living in a low schistosomiasis transmission area of China

Parasites & Vectors, 2014
Background In recent field surveys, we failed to detect the presence of specific antibody against Schistosoma japonicum in some egg-positive patients by commonly used immunodiagnostic kits.
Shu-Ying Xie, Min Yuan, Min-Jun Ji, Fei Hu, Zhao-Jun Li, Yue-Min Liu, Xiao-Jun Zeng, Hong-Gen Chen, Hai-Wei Wu, Dan-Dan Lin   +9 more
doaj   +1 more source