Results 221 to 230 of about 1,847,937 (304)

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

open access: yesVIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source

Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow

open access: yesVIEW, EarlyView.
Comprehensive evaluation of metagenomic next‐generation sequencing for pathogen identification in patients with suspected infection: Establishment of a standardized validation workflow. Abstract Metagenomic next‐generation sequencing (mNGS) enables unbiased identification of pathogens directly from clinical specimens. Despite its growing application in
Wen Shu   +11 more
wiley   +1 more source

Association of Cat Sensitization With Comorbid Asthma in Patients With Allergic Rhinitis: A Real‐World Study

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background The prevalence of allergic rhinitis (AR) and asthma (AS) comorbidity (AR + AS) is increasing and is associated with severe allergic symptoms. The impact of cat dander sensitization on AR + AS remains unclear. Methods In this retrospective study, 1154 patients with AR alone and 213 patients with AR + AS were enrolled at the Third ...
Wei‐Hao Wang   +5 more
wiley   +1 more source

Immune Clues to Sinus Blues: Linking Biomarkers to Radiologic Score of Rhinosinusitis

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a prolonged inflammatory condition of the nasal and paranasal sinuses that significantly affects quality of life. This study examines the relationship between CRS severity (based on Lund‐Mackay [LM] scores), osteitis, and systemic inflammatory markers, including neutrophil‐to‐lymphocyte ratio (NLR ...
Lubna Khreesha   +10 more
wiley   +1 more source

Cortisol concentrations in hair are biomarkers of health status and seasonal change, but not urbanisation, in wolves

open access: yesWildlife Biology, EarlyView.
Wolves have reclaimed much of their former range in Europe, including areas with a high human footprint, yet the physiological impacts of human‐associated stressors remain poorly understood. We first examined methodological factors affecting hair cortisol concentrations (HCC) in wolves by using a ‘shave/re‐shave' design to assess hair growth rate and ...
Gwendolyn Wirobski   +15 more
wiley   +1 more source

Behavioral response of moose Alces alces to summer heat stress

open access: yesWildlife Biology, EarlyView.
Minnesota moose are heat‐stressed during summers, which is adversely impacting their survival. We used both movement and activity data to explore the behavioral responses of Minnesota moose experiencing heat stress, termed ‘hot moose events' or HMEs, to understand how both ambient temperature and available habitat contribute to the ability of these ...
Michelle Carstensen   +3 more
wiley   +1 more source

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