Results 71 to 80 of about 1,847,937 (304)

Infection and co-infection with helminths and Plasmodium among school children in Côte d'Ivoire : results from a National Cross-Sectional Survey [PDF]

, 2014
Helminth infection and malaria remain major causes of ill-health in the tropics and subtropics. There are several shared risk factors (e.g., poverty), and hence, helminth infection and malaria overlap geographically and temporally.
Silué, Kigbafori D., Eveline Hürlimann, Utzinger, Jürg, Yapi, Richard B., Ferdinand N Kouamé, Ferdinand N. Kouamé (573277), Penelope Vounatsou, Clarisse A Houngbedji, Richard B. Yapi (424490), Prisca B Ndri, Richard B Yapi, Eliézer K. N’Goran (417750), Gotianwa Soro (573276), Jürg Utzinger, Houngbedji, Clarisse A., Giovanna Raso, Giovanna Raso (51489), Ndri, Prisca B., Prisca B. Ndri (573275), Raso, Giovanna, Gotianwa Soro, Clarisse A. Houngbedji (573274), Jürg Utzinger (39609), Eveline Hürlimann (217729), Penelope Vounatsou (49253), Thomas Fürst (128978), Kigbafori D. Silué (128980), Kouamé, Ferdinand N., Eliézer K N'Goran, Thomas Fürst, Soro, Gotianwa, N'Goran, Eliézer K., Hürlimann, Eveline, Kigbafori D Silué, Vounatsou, Penelope, Fürst, Thomas   +35 more
core   +2 more sources

Clinical characteristics and pathogen spectra of parasitic infections in a tertiary hospital of Shanghai: A 13-year retrospective study

Frontiers in Public Health, 2022
BackgroundThis study performed a follow-up investigation of parasitic infections and the evolution of the infection spectra in Shanghai and its surrounding areas in Eastern China.
Jinming Zhang, Jinming Zhang, Jing Xu, Weiliang Tang, Weiliang Tang, Ruidong Mo, Ruidong Mo, Dabao Shang, Dabao Shang, Jie Lu, Jie Lu, Ziqiang Li, Ziqiang Li, Xiaolin Wang, Xiaolin Wang, Dongmei Shi, Dongmei Shi, Qing Xie, Qing Xie, Xiaogang Xiang, Xiaogang Xiang   +20 more
doaj   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Life-history responses, transmission dynamics and epidemiology in a terrestrial gastropod infected with parasitic mites [PDF]

, 2010
Parasites are known to influence the life-history of their hosts. A parasite-induced reduction in host fecundity and survival may lead to a reduced rate of increase in the host population.
Schüpbach, Hans Ulrich
core   +1 more source

Adaptation of Echinococcus Multilocularis to Oxidative Stress Depends on EmPDK‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Metabolic adaption presents a vital survival strategy for E. multilocularis. This study identifies EmPDK as a central metabolic regulator governing glucose metabolic reprogramming. Oxidative stress activates EmHIF1α to induce EmPDK expression. Mechanistic characterization reveals this ROS/EmHIF1α/EmPDK axis drives glycolytic reprogramming to sustain ...
Huijuan Wang, Zhijian Xu, Ye Tian, Yao Zhang, Zhe Cheng, Yanhai Wang   +5 more
wiley   +1 more source

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

The evolution of covert, silent infection as a parasite strategy [PDF]

, 2009
Many parasites and pathogens cause silent/covert infections in addition to the more obvious infectious disease-causing pathology. Here, we consider how assumptions concerning superinfection, protection and seasonal host birth and transmission rates ...
White, Andrew, Boots, Mike, Pedersen, Amy B., Sorrell, Ian, Hails, Rosemary S., White, A, Sorrell, I, Pedersen, AB, Boots, M, White, Andrew; id_orcid, Hails, RS   +10 more
core   +1 more source

Immune responses to Fasciola hepatica infection, and Fasciola hepatica derived antigens [PDF]

, 2003
The aim of this study was to investigate immune responses as a result of infection with the parasitic helminth, Fasciola hepatica. Analysis of IL-4 and Interferon-y cytokines described a predominant type 2 immune response in BALB/c mice infected with ...
Walshe, Alan
core   +1 more source