Results 21 to 30 of about 39,205 (266)

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Intestinal parasitic infections and associated factors among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis.

PLoS ONE, 2020
BackgroundIntestinal parasitic infections are major public health problems throughout the world, particularly in people living with HIV/AIDS. People living with HIV/AIDS are vulnerable groups for a variety of diseases, hence they are easily affected by ...
Adam Wondmieneh, Getnet Gedefaw, Birhan Alemnew, Addisu Getie, Melaku Bimerew, Asmamaw Demis   +5 more
doaj   +1 more source

IL‐7R‐Enriched Extracellular Vesicles From the Thymus Drive Colitis via Promoting Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao, Yuheng Liu, Ruibing Yang, Zifeng Zhu, Junwei Wu, Dinghao Li, Jin Su, Yingxin He, Shiqi Luo, Feiyang Cao, Haiyi Deng, Lanmengxi Yang, Ling Zhong, Peiying Peng, Xinyi Wu, Chunmei Cai, Zhen Li, Yujin Wu, Shuofeng Zhu, Jie Wei, Yi Yang, Lifu Wang   +21 more
wiley   +1 more source

ProSiteHunter: A Unified Framework for Sequence‐Based Prediction of Protein‐Nucleic Acid and Protein‐Protein Binding Sites

Advanced Science, EarlyView.
This study proposed a unified sequence‐based framework for protein binding site prediction, which adopted a tri‐track semantic multi‐source feature fusion strategy to effectively capture diverse macromolecular interaction sites and further improved the accuracy of antibody‐antigen interaction prediction.
Dongliang Hou, Qihang Zhen, Zexin Lv, Xinyue Cui, Suhui Wang, Minghua Hou, Zhan Zhou, Xiaogen Zhou, Guijun Zhang   +8 more
wiley   +1 more source

Intestinal parasite infections and associated factors among inmates of Arba Minch prison, southern Ethiopia: cross sectional study

BMC Infectious Diseases, 2019
Background Intestinal parasitic infection is one of the parasitic infections affecting people living in prison. Helminths and intestinal protozoan infections are the most common parasitic infection that may cause serious life-threatening diseases in ...
Gemechu Ameya, Zerihun Zerdo, Mihret Tesfaye, Chimdo Jabesa, Abayneh Awaje, Kaleb Dejene, Petros Shika, Mohammed Eshetu   +7 more
doaj   +1 more source

Progression of the load of waterborne and intestinal parasitic diseases in the State of Amazonas

Revista da Sociedade Brasileira de Medicina Tropical, 2015
In the State of Amazonas, Brazil, urban expansion together with precarious basic sanitation conditions and human settlement on river banks has contributed to the persistence of waterborne and intestinal parasitic diseases.
Marilaine Martins, Marcus Vinícius Guimarães Lacerda, Wuelton Marcelo Monteiro, Marco Antonio Saboia Moura, Eyde Cristianne Saraiva Santos, Valéria Saraceni, Maria Graças Gomes Saraiva   +6 more
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Study the Frequency of Intestinal Parasites and its Association with Clinical Symptoms in Patients who Referred to Hamadan Health Centers in 1998-99

پزشکی بالینی ابن سینا, 2001
Intestinal   protozoa  and   helminths  are  aetiological  agents of several    widespread   parasitic   diseases. The   most common ones are Entamoeba    histolytica , Giardia lamblia and Ascaris lumbricoides.
Khosro Sardarian
doaj  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Parasitismo intestinal infantil: factores epidemiológicos en Orange Walk, Belice Intestinal parasitism in children: epidemiological factors in Orange Walk, Belize

Revista de Ciencias Médicas de Pinar del Río, 2011
El parasitismo intestinal (PI) continúa siendo un problema de salud en Centroamérica y el Caribe. Se realizó una investigación aplicada, epidemiológica, descriptiva, transversal, en el Distrito urbano de Orange Walk, (Belice), año 2009, con el objetivo ...
Liset Corrales Fuentes, Sandra Hernández García, Miguel Angel Rodríguez Arencibia, Aydely Hernández Pérez   +3 more
doaj