Results 11 to 20 of about 872 (151)

Central Nervous System-Active Medications and Risk of Hospital Readmission in Older Multimorbid Adults. [PDF]

J Am Geriatr Soc
ABSTRACT Background Polypharmacy is associated with adverse outcomes, particularly in older multimorbid adults. However, little is known about the negative outcomes associated with multiple central nervous system (CNS)‐active medications that are commonly prescribed to these patients. Objective To assess the association between the number of CNS‐active
Stuber MJ, Brockhus LA, Spinewine A, O'Mahony D, Jennings E, Dalleur O, Knol W, Koek HL, Baggio S, Rodondi N, Aubert CE.   +10 more
europepmc   +2 more sources

Are muscarinic agonists and acetylcholinesterase inhibitors effective for the treatment of underactive bladder? [PDF]

, 2023
Introduction & Objectives: There are a range of mechanisms and systems underlying urinary bladder contractions, with interactions between nerves, endogenously released chemicals and receptors all playing a part in the overall function1,2.
Phelps, Charlotte; id_orcid, Moro, Christian; id_orcid, Veer, Vineesha; id_orcid   +2 more
core   +5 more sources

Effects of Omidenepag Isopropyl Versus Latanoprost Eye Drops on Intraocular Pressure, Pupil Diameter, and Anterior Chamber Parameters in Normal Feline Eyes: A Pilot Study. [PDF]

Vet Ophthalmol
ABSTRACT Objectives This study aimed to compare the effect of the newly developed selective prostaglandin E2 receptor agonist, omidenepag isopropyl (OMDI), and latanoprost on intraocular pressure (IOP), pupil diameter (PD), and anterior chamber parameters in normal feline eyes.
Park SE, Hwang J, Kang N, Jung J, Woo HM, Park KM.   +5 more
europepmc   +2 more sources

The secretory senescence in otorhinolaryngology: principles of treatment [PDF]

, 2020
Atrophy or hypofunction of the salivary gland because of aging, radio-therapy or disease causes hyposalivation and impairs the quality of life of patients by compromising mastication, swallowing and speech and by leading to a loss of taste.
Francesco Antonio Salzano, Melania Tatti, Daniele De Seta, Francesco Barbara, Paolo Petrone, Valeria Marrosu, Giuditta Mannelli, Giacomo Spinato, Daniela Quartu, Flaminia Campo, Anna Berardi, Carlo Berardi, Roberto Puxeddu, Massimo Ralli, Cinzia Mariani, Gabriele Molteni, Valentina Casoli, Filippo Carta, Salvatore Dadduzio, Alfonso Scarpa, Pasquale Capasso, Diletta Angeletti, Stelio Antonio Mocella   +22 more
core   +3 more sources

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner, Kai Rogge, Felix Trottmann, Christian Hertweck, Dirk Hoffmeister   +4 more
wiley   +2 more sources

Design of Experiments, Hirshfeld Surface Analysis, and Pharmacokinetics Predictions of Carbachol‐Loaded Solid Lipid Nanoparticles for Ocular Delivery

ChemistrySelect, Volume 11, Issue 28, 24 July 2026.
Schematic illustration of the carbachol (CCH)–solid lipid nanoparticles (SLN) formulation, highlighting its structural design of experiments (DoE), physicochemical characterization, Hirshfeld surface analysis and pharmacokinetics predictions. ABSTRACT Carbachol (CCH) is a potent acetylcholine receptor agonist of hydrophilic and charged nature, which ...
Valentina Paganini, Raquel da Ana, João G. de Oliveira Neto, Otávio C. da Silva Neto, Adenilson O. dos Santos, Francisco F. Sousa, Patrizia Chetoni, Eliana B. Souto   +7 more
wiley   +1 more source

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva, Joseph Youkilis, Yogith Rao, Alex Straiker   +3 more
wiley   +1 more source

Equine botulism

Equine Veterinary Journal, Volume 58, Issue 2, Page 333-347, March 2026.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source

Identification of Risk Factors in Postoperative Urinary Dysfunction for Rectal Gastrointestinal Stromal Tumors

Annals of Gastroenterological Surgery, Volume 9, Issue 6, Page 1243-1252, November 2025.
Our study aimed to identify the incidence of risk factors for postoperative urinary dysfunction during surgery for rectal gastrointestinal stromal tumors. ABSTRACT Aim Curative resection and organ preservation are important to manage rectal gastrointestinal stromal tumors; however, postoperative quality of life, including urinary function, remains a ...
Jun Kataoka, Yuichiro Tsukada, Masashi Wakabayashi, Daichi Kitaguchi, Hiro Hasegawa, Koji Ikeda, Yuji Nishizawa, Masaaki Ito   +7 more
wiley   +1 more source

Periodontitis presenting among betel quid users: A case series

Clinical Advances in Periodontics, Volume 15, Issue 3, Page 238-245, September 2025.
Abstract Background Betel leaf chewing habit has been studied extensively, as it has been an ancient practice in many Asian countries. Although betel leaf has been reported to have potential beneficial properties, it has also been shown to have a strong association with oral diseases, including periodontitis. This case series addresses the presentation
Jungweon V. Park, Priyanka K. Pitchumani, Dimitris N. Tatakis   +2 more
wiley   +1 more source