Results 111 to 120 of about 119,206 (312)

Parathyroid-hormone-related protein in sarcoidosis

, 1998
Parathyroid-hormone-related protein (PTHrP) is the main mediator of the humoral hypercalcemia of malignancy. It is also detected in many normal adult and fetal tissues.
Hards, DK (15482495), Zhou, H (5397815), Martin, TJ (15482507), Doery, JCG (15482498), Hunter, AN (15482501), Zeimer, HJ (15482489), Grill, V (15482510), Slavin, J (15482492), Duffield, A (15482504), Timothy Greenaway (14737912)   +9 more
core  

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Evolving Pathology of Anaplastic Thyroid Carcinoma: Integrating Morphology, Immunohistochemistry, and Molecular Insights

Cancer Science, EarlyView.
Schematic overview of progression from differentiated thyroid carcinoma (DTC) to anaplastic thyroid carcinoma (ATC). ATC primarily develops via two pathways: the BRAF p.V600E‐mutated papillary thyroid carcinoma (PTC) pathway and the RAS‐mutated pathway. The origin and progression of BRAF/RAS‐wildtype ATC remain unclear.
Toru Odate, Tetsuo Kondo
wiley   +1 more source

Case report: Sagliker syndrome in the patient with recurrent tertiary hyperparathyroidism due to intrathyroidal parathyroid carcinoma

Frontiers in Endocrinology
Sagliker syndrome (SS) is an extremely rare disorder that manifests in patients with advanced chronic kidney disease (CKD) undergoing programmed hemodialysis as a renal replacement therapy.
Rustam Salimkhanov, Ekaterina Bondarenko, Anna Eremkina, Ekaterina Bibik, Ekaterina Kim, Kamila Begova, Ilya Kim, Sergey Kuznetsov, Natalia Mokrysheva   +8 more
doaj   +1 more source

Tumor‐Derived Exosomal piR‐hsa‐28212 Promotes Lymphatic Metastasis in Breast Cancer

Cancer Science, EarlyView.
Breast cancer–derived exosomal piR‐hsa‐28212 promotes lymphangiogenesis and lymph node metastasis by activating VEGFC/VEGFR3 signaling. It stabilizes TBX1 mRNA in lymphatic endothelial cells and METTL3 protein in tumor cells, enhancing VEGFR3 expression and VEGFC secretion.
Yafen Wang, Tianli Zhang, Xue Kong, Yao Tong, Yanru Li, Xiangjun Dong, Chuanxin Wang, Juan Li   +7 more
wiley   +1 more source

Endoscopic thyroidectomy via oral vestibular approach versus areolar approach: A meta-analysis

Asian Journal of Surgery, 2023
Baoying Xia, Zhichao Xing, Yuxuan Qiu, Zhujuan Wu, Ni-re Abuduwaili Mu, Zhe Li, Jingqiang Zhu, Anping Su   +7 more
doaj   +1 more source

Immune microenvironment in papillary thyroid carcinoma: roles of immune cells and checkpoints in disease progression and therapeutic implications

Frontiers in Immunology
Papillary thyroid cancer (PTC) is the most common type of primary thyroid cancer. Despite the low malignancy and relatively good prognosis, some PTC cases are highly aggressive and even develop refractory cancer in the thyroid. Growing evidence suggested
Xun Zheng, Ruonan Sun, Ruonan Sun, Tao Wei   +3 more
doaj   +1 more source

Functional Parathyroid Adenoma Diagnosed After Stress Fractures

, 2008
Clinical findings and radiographs may be disleading or indefinite in patients with insufficiency fractures. Herein, we present a patient with low back pain increasing with activity and morning stiffness, which initially were thought to be due to a ...
Esra Özkavukçu, Nuray Haliloğlu, Gülden Şahin   +2 more
core  

Vitamin D Supplementation to Prevent Post‐Thyroidectomy Hypocalcemia

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Hypocalcemia is the most common complication following thyroidectomy. Previous studies yielded inconsistent results on whether vitamin D3 prevents postoperative hypocalcemia and were conducted in non‐European countries with different dietary habits and baseline vitamin D levels.
Jeresa I. A. Willems, Daan J. L. van Twist, Kristy M. Pickwell, Patrick L. H. van Battum, Rutgert Bianchi, Annette M. Pijnenburg, James van Bastelaar, Marco Medici, Robin P. Peeters, Roderick F.A. Tummers‐de Lind van Wijngaarden   +9 more
wiley   +1 more source

Case report: Relapse of intrathyroidal parathyroid carcinoma in a patient with novel variants in MET and CDKN1C genes

Frontiers in Oncology
Parathyroid carcinoma (PC) is one of the rarest malignant neoplasms of the human endocrine system, with a prevalence of approximately 0.005% of all oncological diseases. Despite its indolent course, PC generally relapses in about 40%–60% of cases.
Ekaterina Kim, Anastasiia Lavreniuk, Olga Spasskaya, Anna Eremkina, Rustam Salimkhanov, Liliya Urusova, Natalia Tarbaeva, Sergey Popov, Victoria Zakharova, Natalia Mokrysheva   +9 more
doaj   +1 more source