Results 71 to 80 of about 14,361 (208)

G Protein‐Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers

MedComm, Volume 6, Issue 10, October 2025.
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Inamu Rashid Khan, Sana Khurshid, Saud Almawash, Rakesh Kumar, Ammira S. Al‐Shabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha   +6 more
wiley   +1 more source

Role of calcium-sensing receptor, Galectin-3, Cyclin D1, and Ki-67 immunohistochemistry to favor in the diagnosis of parathyroid carcinoma

Indian Journal of Pathology and Microbiology, 2018
Background: As histopathological findings of parathyroid carcinoma are not certain, the diagnosis of tumors with degenerative changes may be difficult. In these cases, immunohistochemical markers are beneficial.
Nuran Sungu, Hayriye Tatli Dogan, Aydan Kiliçarslan, Mehmet Kiliç, Sefika Polat, Mehmet Tokaç, Soner Akbaba, Ömer Parlak, Serdar Balci, Betül Ögüt, Bekir Çakir   +10 more
doaj   +1 more source

Ectopic Mediastinal Parathyroid Adenoma in a Patient with Chronic Kidney Disease: A Case Report

대한영상의학회지, 2019
We report an ectopic mediastinal parathyroid adenoma in a patient with chronic kidney disease who presented with refractory hypercalcemia. Technetium-99m-sestamibi scintigraphy is a valuable imaging technique for the detection of an ectopic parathyroid ...
Dong Min Choo, Jin Hwan Kim, Song Soo Kim   +2 more
doaj   +1 more source

Giant Parathyroid Tumor: Parathyroid Adenoma versus Parathyroid Carcinoma

Case Reports in Endocrinology, 2022
Parathyroid adenoma is the most common cause of primary hyperparathyroidism (PHPT). We present the preoperative detection of a giant parathyroid adenoma (GPA) using (99mTc)-sestamibi parathyroid scintigraphy in a patient presenting with severely elevated
Farid Gossili, Allan Carlé, Trine B. Andersen, Helle D Zacho   +3 more
doaj   +1 more source

Combining Procalcitonin and Calcitonin for the Diagnosis of Medullary Thyroid Cancer: A Two‐Step Approach

Clinical Endocrinology, Volume 103, Issue 4, Page 587-595, October 2025.
ABSTRACT Objective Calcitonin (CT) represents the most important biochemical marker of medullary thyroid cancer (MTC), but has certain limits. Procalcitonin (ProCT) has been recognized as an alternative or additional marker for MTC. The aim of the study is to evaluate prospectively the role of ProCT combined with CT in the identification of MTC ...
Cristina Clausi, Simona Censi, Emma Zanin, Giulia Messina, Ilaria Piva, Daniela Basso, Isabella Merante Boschin, Loris Bertazza, Francesca Torresan, Maurizio Iacobone, Fiammetta Battheu, Susi Barollo, Jacopo Maria Arnone, Caterina Mian   +13 more
wiley   +1 more source

Emerging Radiopharmaceuticals Beyond FDG for Ovarian Cancer: A Review of Advances in Nuclear Medicine

Cancer Medicine, Volume 14, Issue 17, September 2025.
Emerging radiopharmaceuticals in nuclear medicine could improve ovarian cancer diagnosis and staging, while also enabling assessment of treatment response, therapy resistance, and suitability for targeted therapies. ABSTRACT Aims This review summarizes the role and future prospects of nuclear medicine in ovarian cancer, focusing on novel ...
Mara M. K. Veenstra, Sophie Veldhuijzen van Zanten, Erik Vegt, Ingrid A. Boere, Heleen J. van Beekhuizen, Julie Nonnekens, Frederik A. Verburg, Maarten G. J. Thomeer   +7 more
wiley   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Abdelhamid, S., Allolio, B., Beuschlein, Felix, Chrousos, G. P., Jaursch-Hancke, C., Karl, M., Reincke, Martin, Travis, W.   +7 more
core  

Spontaneous Near-Remission of Hyperparathyroidism after Parathyroid Crisis

AACE Clinical Case Reports, 2018
: Objective: To describe an unusual case of primary hyperparathyroidism due to a benign cystic parathyroid adenoma involving parathyroid crisis, profoundly elevated serum calcium and parathyroid hormone levels, and near-remission prior to surgery.Methods:
Roy Lirov, MD, Shafaq Kairi, MD, Paul G. Gauger, MD   +2 more
doaj   +1 more source

Postoperative Hypocalcemia Following Parathyroidectomy for Giant Parathyroid Adenoma

AACE Clinical Case Reports, 2020
: Objective: Giant parathyroid adenomas (GPAs) are a rare type of parathyroid adenoma (PA) weighing >2 to 3 g. The objective of this manuscript is to report a case of giant parathyroid adenoma and highlight the risk of postoperative hypocalcemia ...
Rishi Raj, MD, Adele Amine, MD, Demetrios Herodotou, MD   +2 more
doaj   +1 more source

Carcinoma de paratiróide: características clínicas e anátomo-patológicas de cinco casos [PDF]

, 2001
Parathyroid carcinoma is a rare disease, with about 535 cases reported in the literature until now. In this paper, we reviewed 5 cases of parathyroid carcinoma followed at Universidade Federal de São Paulo (UNIFESP) from 1983 to 1998, and discuss aspects
Abrahão, Márcio, Alberti, Vânia N., Cervantes, Onivaldo, Goulart, Marcio L., Hauache, Omar M., Lazaretti-Castro, Marise, Morimitsu, Lilian K., Uyeno, Monique N.o., Vieira, José Gilberto H.   +8 more
core   +4 more sources