Results 71 to 80 of about 1,155,277 (353)

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

Genes & Development, 1994
The parathyroid hormone-related peptide (PTHrP) gene was disrupted in murine embryonic stem cells by homologous recombination, and the null allele was introduced into the mouse germ line.
A. Karaplis, A. Luz, Julia Glowacki, R. Bronson, V. Tybulewicz, H. Kronenberg, R. Mulligan   +6 more
semanticscholar   +1 more source

Advances in Molecularly Imprinted Polymers for Bone Biomarker Detection and Therapeutic Applications

ChemistryOpen, EarlyView.
This review highlights the emerging applications of molecularly imprinted polymers (MIPs) in bone regeneration and diagnosis. MIPs facilitate osteogenic treatments by guiding stem cell differentiation and delivering bioactive molecules and enable precise detection of bone turnover biomarkers via MIP‐based sensors, offering promising strategies for next‐
Ren Yang, Xiaohan Ma, Mingcheng Xuan, Yingqi Ma, Jiexian Ding, David Y. S. Chau, Jonathan C. Knowles, Feng Peng, Alessandro Poma   +8 more
wiley   +1 more source

Revisiting the Incidence of Hypercalcemia in Contemporary Diagnoses of Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Hypercalcemia is rarely observed in pediatric patients with cancer. However, rare cases of renal insufficiency and osteoporosis have been reported as severe consequences. Published literature focuses predominantly on hypercalcemia in pediatric hematologic malignancies, precluding causative associations with solid tumor disease ...
Felicia Y. Ho, Dajana Alku, Chalinee Monsereenusorn, Nan Chen, Wendy B. London, Allison F. O'Neill   +5 more
wiley   +1 more source

State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna, Amitava Mitra, Matthew L. Zierhut, Lilly East, Chandra Durairaj   +4 more
wiley   +1 more source

Successful medical management of eclampsia in a canine 9 weeks postpartum

Veterinary Record Case Reports, EarlyView.
Abstract A 2‐year‐old, entire, female Golden Retriever/Great Pyrenees mix presented with acute lethargy, ptyalism and hyperthermia approximately 9 weeks postpartum. It had whelped 11 puppies, and clinical signs began suddenly at weaning with lethargy and excessive salivation.
Taylor N. Baird, Charles T. Talbot, Alexandria Horner, Kristin M. Zersen   +3 more
wiley   +1 more source

Parathyroid Hormone Sampling From the Anterior Jugular Vein Versus Peripheral Vein After Total Thyroidectomy

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background To determine if anterior jugular vein sampling (AJVS) is non‐inferior to peripheral venous sampling (PVS) for measuring intraoperative parathyroid hormone (PTH) levels following total thyroidectomy. Methods This was a prospective non‐inferiority trial conducted at a tertiary academic medical center.
Noel M. Phan, Keva Li, Eleni A. Varelas, Caleb J. Fan, Raymond L. Chai   +4 more
wiley   +1 more source

A practical self-made device in parathyroid autotransplantation for patients with secondary hyperparathyroidism

Journal of International Medical Research, 2019
Objective Secondary hyperparathyroidism (sHPT) is one of the most serious complications in patients on long-term hemodialysis. These patients may suffer from metabolic bone diseases, severe atherosclerosis, and undesirable cardiovascular events ...
Lei Du, Xiwei Zhang, Liang Yan, Hao Zhang, Xuefeng Tang, Xiancheng Kong, Gang Liu, Jianping Huang   +7 more
doaj   +1 more source

Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial

BMC Endocrine Disorders, 2012
Background Increasing evidence suggests the bidirectional interplay between parathyroid hormone and aldosterone as an important mechanism behind the increased risk of cardiovascular damage and bone disease observed in primary hyperparathyroidism.
Tomaschitz Andreas, Fahrleitner-Pammer Astrid, Pieske Burkert, Verheyen Nicolas, Amrein Karin, Ritz Eberhard, Kienreich Katharina, Horina Jörg H, Schmidt Albrecht, Kraigher-Krainer Elisabeth, Colantonio Caterina, Meinitzer Andreas, Pilz Stefan   +12 more
doaj   +1 more source

Impact of barometric pressure on blood pressure during dialysis: Introducing intradialytic time‐averaged cumulative systolic blood pressure (TACsBP‐inD) as a new metric

Therapeutic Apheresis and Dialysis, Volume 29, Issue 3, Page 525-534, June 2025.
Abstract Background Blood pressure is a crucial risk factor for hemodialysis patients, but the specific impact of weather factors, particularly barometric pressure, on blood pressure remains unclear. This study aims to examine the relationship between barometric pressure and blood pressure in hemodialysis patients. Methods We conducted a single‐center,
Kosaku Iwatsubo, Shouichi Fujimoto, Michikazu Nakai   +2 more
wiley   +1 more source

Different parts of the mussel Gigantidas haimaensis holobiont responded differently to deep‐sea sampling stress

Integrative Zoology, EarlyView.
Symbiotic gill and nonsymbiotic mantle of mussel Gigantidas haimaensis responded differently to deep‐sea sampling stress caused by acute environmental changes. Sharply increased transcription factors potentially play key roles in initiating the response of sampled deep‐sea macrobenthos to the sampling stress.
Guoyong YAN, Tong WEI, Yi LAN, Ting XU, Peiyuan QIAN   +4 more
wiley   +1 more source