Results 191 to 200 of about 460,523 (244)
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Vascular Effects of Parathyroid Hormone (PTH)
1982PTH causes dose dependent transient vasodilatation in various vascular beds, specifically renal, coeliac, coronary, but not osseous. It has an acute dose-dependent hypotensive effect in the intact animal which is not mediated by alpha- or beta-adrenergic, cholinergic or histaminergic mechanisms.
M, Rambausek +6 more
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Endocrinology, 1994
Abstract The PTH/PTH-related peptide receptor is a member of a newly discovered family of G-protein-coupled receptors. Strikingly conserved features among these receptors include the positioning of eight extracellular cysteines and several other residues that are located predominantly within the membrane-embedded region.
C, Lee +7 more
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Abstract The PTH/PTH-related peptide receptor is a member of a newly discovered family of G-protein-coupled receptors. Strikingly conserved features among these receptors include the positioning of eight extracellular cysteines and several other residues that are located predominantly within the membrane-embedded region.
C, Lee +7 more
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Endocrinology, 1988
Human PTH (hPTH)-(3-84) and hPTH-(8-84) were synthesized in Escherichia (E.) coli when the cells were transformed with a multicopy plasmid in which the transcription of human preproPTH cDNA is directed by the E. coli lac promoter. PTH fragments were extracted from cells and purified by reverse phase HPLC.
W, Born +5 more
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Human PTH (hPTH)-(3-84) and hPTH-(8-84) were synthesized in Escherichia (E.) coli when the cells were transformed with a multicopy plasmid in which the transcription of human preproPTH cDNA is directed by the E. coli lac promoter. PTH fragments were extracted from cells and purified by reverse phase HPLC.
W, Born +5 more
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Conformational studies of parathyroid hormone (PTH)/PTH-related protein (PTHrp) chimeric peptides
Biopolymers, 2000The N-terminal 1-34 segments of both parathyroid hormone (PTH) and parathyroid hormone-related protein (PTHrP) bind and activate the same membrane-embedded G protein-coupled receptor (PTH1 Rc) present on the surface of cells in target tissues such as bone and kidney.
SCHIEVANO, ELISABETTA +6 more
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The Journal of Clinical Endocrinology & Metabolism, 1988
Most studies of circulating PTH levels using traditional RIAs have supported the concept of physiological hyperparathyroidism of pregnancy, with pregnant women having serum immunoreactive PTH levels significantly higher than those in nonpregnant subjects.
O K, Davis +5 more
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Most studies of circulating PTH levels using traditional RIAs have supported the concept of physiological hyperparathyroidism of pregnancy, with pregnant women having serum immunoreactive PTH levels significantly higher than those in nonpregnant subjects.
O K, Davis +5 more
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Metabolism of Parathyroid Hormone and Interpretation of Radioimmunoassays for PTH
1985With the development of radioimmunoassays that are specific for certain regions of the parathyroid hormone (PTH) molecule, the fate of PTH that is secreted into the circulating blood has been partially clarified.
Eduardo Slatopolsky +3 more
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The Effects of Parathyroid Hormone (PTH) on Ca Transport
1991Parathyroid hormone (PTH) stimulates active Ca2+ reabsorption in the distal convoluted tubule of the rat and in the cortical connecting tubule, distal convoluted tubule, and granular portion of the cortical collecting tubule of the rabbit. The dominant mechanism of Ca2+ reabsorption in the proximal tubules is passive diffusion via the paracellular ...
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[Roles of parathyroid hormone (PTH) on phosphate metabolism].
Clinical calcium, 2005Changes in the extracellular concentration of inorganic phosphate (Pi) modulate cellular function in a physiologically relevant manner. High serum Pi leads to an increase in PTH secretion, PTH mRNA stability, and parathyroid cell (PT) proliferation.
Mikiko, Ito +2 more
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[Compounds modulating parathyroid hormone (PTH) secretion].
Clinical calcium, 2005The control of parathyroid hormone (PTH) secretion is strictly regulated by the parathyroid Ca receptor (CaR). Calcimimetics and calcilytics selectively act on the parathyroid CaR to inhibit and enhance PTH secretion, respectively. According to the recent pharmacological two-state model, calcimimetics act on the CaR as allosteric agonists to stabilize ...
N, Nagano, H, Iijima
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