Results 91 to 100 of about 145,553 (265)

MEN1 Deficiency Drives Lung Cancer Progression via Activation of MMP10‐Mediated Angiogenesis

Cancer Science, EarlyView.
MEN1 deficiency promotes JunD‐mediated upregulation of MMP10 expression, which cleaves pro‐HB‐EGF and activates endothelial EGFR. This triggers the PI3K/Akt and MEK/ERK signaling pathways, thereby driving angiogenesis and tumor progression. MMP10 inhibitor treatment blocks this cleavage, suppresses EGFR signaling, and thereby delays malignant ...
Chengyu Wei, Xiangyu Liu, Shimin Hu, Xiaodie Shen, Yingli Liu, Xinxin Qin, Ye Zhou, Jianqi Zheng, Bingke Tian, Jingfang Hong, Yongxia Song, Di Wang, Linlin Peng, Jinxia Ding, Fang Wang, Hui Zhang, Shihao Zhang, Huan Qiu   +17 more
wiley   +1 more source

Japanese Society for Hereditary Tumors Guidance: Hereditary Cancer Syndromes With Multigene Panel Testing, 2025 Edition

Cancer Science, EarlyView.
Schematic of the clinical algorithm for diagnosing hereditary cancer syndromes using MGPT. ABSTRACT In March 2025, the Japanese Society for Hereditary Tumors and the Ministry of Health, Labour and Welfare (MHLW) Research on Promotion of Cancer Control Program Grant Number JPMH 23EA1037 published the “Japanese Society for Hereditary Tumors Guidance ...
Reiko Yoshida, Akira Hirasawa, Issei Imoto, Tatsuro Yamaguchi, Kensuke Kumamoto, Momoko Araki, Arisa Ueki, Kenta Masuda, Yusaku Urakawa, Noriko Tanabe, Atsushi Watanabe, Makoto Hirata, Tomoyuki Aruga, Takeshi Kuwata, Yoshinaga Okugawa, Keika Kaneko, Hiroko Terui‐Kohbata, Megumi Matsumoto, Sayaka Ueno, Katsutoshi Oda, Hisako Ono, Akihiro Sakurai, Hirotaka Matsui, Gou Yamamoto, Hideki Yamamoto, Yasuko Yamamoto, Masachika Ikegami, Yusuke Ohkuma, Kazuhiko Shien, Shigenobu Suzuki, Shunsaku Takayanagi, Masahiko Tanabe, Hisashi Hasumi, Naohito Hatta, Hiroyoshi Hattori, Hiroyuki Matsubayashi, Wataru Yamagami, Masayoshi Yamada, Kazuyuki Oishi, Tomomi Oka, Shinya Oda, Yusuke Kobayashi, Kazuhiro Takekoshi, Takeshi Nakajima, Yoshiko Nakano, Yoshiko Nakayama, Fumiharu Miura, Yasuyuki Miyakura, Yoshiko Mori, Akiyo Yoshimura, Masato Yonamine, Kunitoshi Shigeyasu, Hiroko Fujita, Mashu Futagawa, Kouji Ohta, Junko Kawano, Tomoharu Tokutomi, Ayaka Sato, Takeshi Makabe, Tomoko Yoshihama, Miki Aitani, Kaori Kimura, Nabue Takaiso, Chikako Tomozawa, Yumie Hiraoka, Manami Matsukawa, Hideyuki Ishida   +66 more
wiley   +1 more source

Hypophosphataemia in adults: approach to diagnosis and management

Internal Medicine Journal, EarlyView.
Abstract Hypophosphataemia is a common electrolyte disorder which can have clinically significant consequences for bone, muscle, neurological and haematological function. Its causes range from transient transcellular shifts in hospitalised patients to chronic renal phosphate‐wasting disorders mediated by fibroblast growth factor 23 (FGF23).
Kajanan Parameshwaran, Mawson Wang, Kirtan Ganda   +2 more
wiley   +1 more source

Parathyroid Cancer

, 2012
Parathyroid carcinoma is a rare endocrine malignancy derived from the parenchymal cells of the parathyroid glands. It is usually associated with more severe and profound clinical and laboratory manifestations than its more common benign counterparts. Its
IACOBONE, MAURIZIO, HENRY JF
core   +1 more source

Mucinous Neoplasms

, 2022
Mucinous cystic neoplasms (MCNs) are thick-walled, uni- or multilocular tumors composed of mucin-containing cysts. These neoplasms occur almost exclusively in women and are mainly located in the body-tail of the pancreas.
D'Onofrio, Mirko, Capelli, Paola, Martini, Paolo Tinazzi, Barbi, Emilio, Luchini, Claudio, De Robertis, Riccardo   +5 more
core   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Two rare tumors, one patient: The first report of bilateral mixed corticomedullary tumors of the adrenal gland

UroPrecision, EarlyView.
Reza Kaffash Nayeri, Farshad Banouei, Tina Darehzari, Benyamin Mohammadi   +3 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

A retrospective study on a nomogram combining clinical and ultrasound parameters for differentiating solitary parathyroid adenoma from carcinoma or atypical tumors

Frontiers in Endocrinology
ObjectiveParathyroid carcinoma (PC) and atypical parathyroid tumor (APT) are rare malignant parathyroid disorders with varying degrees of recurrence risk.
Chunrui Liu, Mingxia Li, Wenxian Li, Haiyan Xue, Yidan Zhang, Shuping Wei, Jian He, Jing Yao, Zhengyang Zhou   +8 more
doaj   +1 more source

Two cases synchronous atypical parathyroid adenomas and papillary thyroid carcinoma

Клиническая и экспериментальная тиреоидология, 2018
Most clinicians are well aware of the coexistence of medullary thyroid cancer and hyperparathyroidism in hereditary and sporadic multiple endocrine neoplasia syndromes.
Iya A. Voronkova, Anastasiya M. Lapshina, Larisa E. Gurevich, Ludmila Ya. Rozhinskaya, Timur A. Britvin, Alexey V. Krivosheev, Ilya V. Kim, Sergey N. Kuznetsov, Natalia G. Mokrysheva   +8 more
doaj   +1 more source