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Epigenetic processes in sporadic parathyroid neoplasms
Molecular and Cellular Endocrinology, 2018Parathyroid tumors (PTs) are highly variable in their genetic background. Increasing evidence demonstrates that endocrine diseases can be caused by epigenetic alterations. The present review is focused on epigenetic aberrations related to PTs. DNA methylation, posttranslational histone modification, and noncoding RNAs are epigenetic mechanisms involved
Angelica M Silva
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EZH2 and ZFX oncogenes in malignant behaviour of parathyroid neoplasms
Endocrine, 2016 Several studies reported somatic mutations of many genes (MEN1, CTNNB1, CDKIs and others) in parathyroid adenoma, although with different prevalence. Recently, activating mutations of the EZH2 and ZFX oncogenes were identified in benign parathyroid adenoma by whole exome sequencing. The same mutations had been found in blood and ovary malignant tumours.
E. Sanpaolo +11 more
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Thyroid and Parathyroid Neoplasms
Medical Radiology, 2011This chapter offers an overview of the epidemiology and aetiology, clinical and histological characteristics and classification, and staging of thyroid and parathyroid neoplasms before providing a more focused and illustrated description of the imaging findings. The indications and the role of ultrasound, ultrasound-guided fine needle aspiration, cross-
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Spectrum of mitochondrial genomic variation in parathyroid neoplasms
Endocrine, 2021Mitochondrial DNA (mtDNA) variations have been implicated in various cancer types. Several attempts have been made in benign parathyroid adenoma (PA); however, mtDNA variants and copy number alterations have not been investigated in parathyroid carcinoma (PC).
Ya Hu +7 more
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Differentiating Atypical Parathyroid Neoplasm from Parathyroid Cancer
Annals of Surgical Oncology, 2016The differentiation of benign parathyroid gland atypia and true parathyroid carcinoma (PC) can be challenging. In some instances, patients are classified as having 'atypical parathyroid neoplasms' (APNs), explicitly acknowledging that the distinction between benign and malignant disease appears impossible to determine.
Ioannis, Christakis +9 more
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Parathyroid Neuroendocrine Neoplasms
2020The parathyroid glands are the site of common benign neuroendocrine tumors, including adenomas and lipoadenomas. Metastatic disease is very rare, and local growth does not usually have significant sequelae; even large non-metastatic tumors are easily resected.
Sylvia L. Asa, Ozgur Mete
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Thyroid and Parathyroid Neoplasms
2020The thyroid and adjacent parathyroid glands demonstrate a variety of benign and malignant pathology, with nodular thyroid disease being the most common pathology encountered in most routine head and neck imaging practice. A variety of thyroid cancers exist, and imaging strategy for staging, surveillance and follow-up depend upon the cancer type.
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The Unequal Distribution of Parathyroid Neoplasms in Male Patients
The American Surgeon™, 2013There is a known lesser incidence of primary hyperparathyroidism and parathyroid neoplasms in male patients. Any difference in the anatomic distribution between males and females has not been documented. Review of our institutional experience with 125 pathologically confirmed parathyroid adenomas (119) or carcinomas (six) from 2000 through 2012 was ...
Bryan, Goldner +2 more
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Analysis of Parathyroid Neoplasms by Interphase Fluorescence In Situ Hybridization
The American Journal of Surgical Pathology, 2004Recent studies have indicated that numerical chromosomal abnormalities, including changes in cyclin D1 and p53, may be involved in parathyroid tumorigenesis. We analyzed a series of parathyroid neoplasms with DNA fluorescent probes to evaluate the diagnostic and prognostic utility of numerical abnormalities of chromosomes 1, 6, 9, 11, 13, 15, 17, and ...
Lori A, Erickson +5 more
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Thyroid and Parathyroid Neoplasms
2006X-rays of the neck, the chest or barium swallows can give hints mainly regarding thyroid disease, such as narrowing of tracheal, hypopharyngeal or oesophageal lumen, their shifting away from the midline, and coarse calcifications (Fig. 14.1). Their importance has remarkably decreased since the development and refinement of modern cross-sectional ...
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