Results 151 to 160 of about 2,189,457 (236)

A Portal‐Preorganized Cucurbit[7]uril‐Ruthenium Conjugate Enables Motif‐Selective Protein Sensing

open access: yesAngewandte Chemie International Edition, EarlyView.
Reprogramming cucurbit[7]uril (CB7) recognition through portal engineering transforms an optically silent host into a motif‐selective photoluminescent receptor. The portal‐preorganized CB7‐Rubpy conjugate directly reports changes in aromatic motif accessibility, enabling optical sensing of protein misfolding and refolding.
Patrick Gruhs   +10 more
wiley   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

open access: yesAngewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann   +10 more
wiley   +1 more source

The role of editorial boards in shaping scholarly communication: A large‐scale mapping of their composition and structure

open access: yesJournal of the Association for Information Science and Technology, EarlyView.
Abstract Editorial boards play a central role in shaping scholarly communication by influencing what research is published and how disciplinary boundaries are defined. Despite their importance, large‐scale, systematic evidence on their composition and structure remains limited.
Evangelina Becerra‐Rodero   +1 more
wiley   +1 more source

String Figuring young children's perspectives of quality in English early childhood education and care

open access: yesBritish Educational Research Journal, EarlyView.
Abstract Quality in early childhood education and care (ECEC) is a contested concept and has generally been conceptualised by inter‐related indicators such as staff qualifications, educational environment, policy or child‐to‐staff ratios. There has been a more limited emphasis on how young children might perceive and experience quality.
Nikki Fairchild, Éva Mikuska
wiley   +1 more source

Child Wellbeing in Two-Parent Families: How Do Characteristics and Relationships Matter? [PDF]

open access: yes
We use data from the Fragile Families and Child Wellbeing Study to examine the role of individual and family characteristics, as well as mother-father and parent-child relationships, with regard to differences in wellbeing for children living with their ...
Sara S. McLanahan, Lawrence M. Berger
core  

Reception Baseline Assessment and ‘small acts’ of micro‐resistance

open access: yesBritish Educational Research Journal, EarlyView.
Abstract In September 2021, following the global COVID‐19 pandemic, the Department for Education introduced a national standardised digital Reception Baseline Assessment (RBA) for all English 4‐year‐old children. We analyse RBA and its associated Quality Monitoring Visits, as a further intensification of the new public management of early years ...
Guy Roberts‐Holmes   +2 more
wiley   +1 more source

Listening to young children with disabilities: Experiences of quality in mainstream primary education

open access: yesBritish Educational Research Journal, EarlyView.
Abstract All children should have access to quality education through a child‐centred pedagogy. An inclusive, child‐centred pedagogy uses a strength‐based view of children that recognises each child as unique and competent, providing children with multiple opportunities to explore and learn at their own pace.
Katherine Gulliver
wiley   +1 more source

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