Advanced Science, EarlyView.NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang +8 more
wiley +1 more source
Advanced Science, EarlyView.This study introduces a versatile platform for quantifying three dimensional traction forces at bio‐adhesive interfaces. Integrating in situ stereo‐digital image correlation with finite element simulations allows for precise measurement of microscale displacements and traction forces in both dry and wet conditions.
Yingwei Hou, Fusheng Wang, Tao Liu
wiley +1 more source
Psychometric properties of the Marschak Interaction Method of Psychometrics and the Assessment of Parent-Child Interaction within residential care and non-referred settings. [PDF]
Front Psychol, 2023 Jacobsen SL +3 more
europepmc +1 more source
Advanced Science, EarlyView.Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang +14 more
wiley +1 more source
Parent-child interaction and early pragmatic, auditory and linguistic abilities in deaf children. [PDF]
Acta Otorhinolaryngol ItalZagari F +6 more
europepmc +1 more source
Applying the Theoretical Domains Framework to Develop an Intervention to 'Re-implement' Parent-Child Interaction Therapy (PCIT). [PDF]
Adm Policy Ment Health, 2023 Woodfield MJ +5 more
europepmc +1 more source
A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging
Advanced Science, EarlyView.Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen +3 more
wiley +1 more source
Navigating Trade-Offs in Early Math: How Informational Priming Influences Parent-Child Interaction. [PDF]
Child DevLu L, Vasilyeva M, Laski EV.
europepmc +1 more source
Scientific collaborations and research trends in Parent-Child Interaction Therapy: a bibliometric analysis. [PDF]
Front Psychol, 2023 Ulaş S +3 more
europepmc +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source