Results 61 to 70 of about 420,147 (288)

Проблема оптимизации детско-родительских взаимоотношений в неполной семье [PDF]

, 2018
THE PROBLEM OF OPTIMIZATION OF CHILD-PARENTAL RELATIONS IN THE INCOMPLETE FAMILY E. KOVALEVA, I. SULIMAРассматривается проблема изучения детско-родительских взаимоотношений в неполной семье. Представлена актуальность исследования, которая определяется,
Ковалёва, Е. А., Сулима, И. В.   +1 more
core   +1 more source

A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence [PDF]

, 2017
OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood.
Asarnow, Joan R., Langer, David A., Sugar, Catherine A., Tompson, Martha C.   +3 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Telehealth for expanding the reach of early autism training to parents. [PDF]

, 2012
Although there is consensus that parents should be involved in interventions designed for young children with autism spectrum disorder (ASD), parent participation alone does not ensure consistent, generalized gains in children's development.
Rogers, Sally J, Vismara, Laurie A, Young, Gregory S   +2 more
core   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Childhood loneliness as a predictor of adolescent depressive symptoms: an 8-year longitudinal study [PDF]

, 2009
Childhood loneliness is characterised by children’s perceived dissatisfaction with aspects of their social relationships. This 8-year prospective study investigates whether loneliness in childhood predicts depressive symptoms in adolescence, controlling ...
A Gerson, A Henin, A Marcoen, AM Sund, B Birmaher, BG Tabachnick, BM Hagerty, C Connors, DCR Kerr, DM Ferguson, DM Ferguson, DW Nangle, E Cowen, E Fombonne, ES Buhs, GW Ladd, J Adams, J Cohen, J Flora, J Kistner, JB Kupersmidt, JD Coie, JE Dumas, JE Young, JH Valery, JL Borelli, JL Luby, JM Martin, JT Cacioppo, JT Cacioppo, KD Rudolph, Ken J. Rotenberg, KJ Rotenberg, L Goossens, L Murry, LA Peplau, LC Hawkley, LD Leve, LJ Koenig, LJ Koenig, LL Carstensen, LS Aiken, LY Abramson, M Boivin, M Brendgen, M Kovacs, M Rutter, MJ Prinstein, NK Eberhart, P Qualter, P Qualter, P Qualter, Pamela Qualter, PD Renshaw, Penny Munn, R Heikkinen, RP Lorion, RP Weissberg, S Harter, S Hymel, S Lau, S Nolen-Hoesksema, S Pederson, Stephen L. Brown, WF Panak, WT Boyce   +65 more
core   +5 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Parent–Child Interaction Therapy: current perspectives

Psychology Research and Behavior Management, 2017
Corey C Lieneman, Laurel A Brabson, April Highlander, Nancy M Wallace, Cheryl B McNeil Department of Psychology, West Virginia University, Morgantown, WV, USA Abstract: Parent–Child Interaction Therapy (PCIT) is an empirically ...
Lieneman CC, Brabson LA, Highlander A, Wallace NM, McNeil CB   +4 more
doaj  

Occupational Therapy’s Role in Early Language Development of Babies and Young Children [PDF]

, 2018
Occupational therapy practitioners in their interactions with babies, young children and their families, can be change-agents who promote rich language environments as a foundation to social interactions, social participation and academic successes. OTPs
Ketchum, OTD, OTR/L, Aimee E., Potvin, PhD, OTR/L, Marie-Christine   +1 more
core   +1 more source

Improving Behavioural and Social Skills in Children with Down Syndrome through Parent-Child Interaction Therapy: Effects on Parenting Skills and Stress in Caregivers

International journal of psychiatry, 2023
This study aimed to shed light on the available intervention tools for children with Down syndrome and their caregivers. Based on evidence gathered from past research, four hypotheses were formed which were tested by four different standardized tests ...

semanticscholar   +1 more source