Results 61 to 70 of about 7,461,237 (234)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The cornerstone of quality in family day care and child care centres – parent-professional partnerships [PDF]

, 2001
Introduction This booklet aims to present a \u27picture\u27 about parent-professional partnerships in a practical and relevant way that can support continuous improvement in family day care and centre based child care.
Anne Stonehouse
core  

From Parent to Child to Parent: Associations Between Parent and Offspring Psychopathology

, 2021
Parental psychopathology can affect child functioning, and vice versa. We examined bidirectional associations between parent and offspring psychopathology in 5,536 children and their parents. We asked three questions: (a) are parent-to-child associations
Hillegers, Manon H.j., Yllza Xerxa, Jan van der Ende, Leslie A. Rescorla, Hillegers, Manon, Xërxa, Y, Ende, Jan, Henning Tiemeier, Verhulst, Frank C., Tiemeier, Henning, Rescorla, LA, van der Ende, J. (Jan), Manon H.J. Hillegers, Xerxa, Yllza, Rescorla, Leslie A., Frank C. Verhulst, Verhulst, Frank   +16 more
core   +1 more source

Birr al-Walidain Konsep Relasi Orang Tua dan Anak dalam Islam [PDF]

Buletin Psikologi, 2017
n the family, parent-child relationship deemed to be a complicated relationship. Parents as adult individuals who have the necessity to educate will tend to straighten up their children.
Nur I'anah
doaj  

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

LEGISLATIVE POLICIES AND CULTURE ON PARENTING PRACTICES: improving the parent-child relationship in South Africa

Revista de Políticas Públicas, 2019
Parent-child relationships are often described as unique and enduring bonds that take place between a caregiver/parent and their child. Several South African legislative policy documents have been implemented to guide service delivery to families and to ...
Edna G. Rich, Nicolette V. Roman
doaj  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Parenting in the age of social media: The buffering effect of parental self-efficacy on the relationship between parental social media use and parent child-relationship quality

Acta Psychologica
The widespread use of technology in daily life has raised concerns about its potential to disrupt social relationships, particularly within one of the most important human relationships: the parent-child relationship. This study assesses whether parental
Celeste Tipple, Cindy Branch-Smith
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source