Results 91 to 100 of about 230,725 (258)
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Inter-rater reliability of treatment fidelity and therapeutic alliance measures for psychological therapies for anxiety in young people with autism spectrum disorders [PDF]
, 2014 Objectives: This article presents work undertaken to establish inter-rater reliability for a measure of treatment fidelity and a measure of therapeutic alliance for therapies for anxiety for young people with autism spectrum disorders. The discussion and
Brown, Rachel +7 more
core +1 more source
Embedded CRISPRi Enhances Gene‐Silencing Efficiency in Drosophila
Advanced Science, EarlyView.Current CRISPR interference (CRISPRi) technology in Drosophila has limited efficiency. This study introduces the emCRISPRi platform, which significantly enhances transcriptional silencing efficacy by embedding inhibitory domains within the dCas9 architecture.
Pengchong Fu +7 more
wiley +1 more source
Advanced Science, EarlyView.This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber +12 more
wiley +1 more source
From Promise to Practice: Mental Health Models That Work for Children and Youth [PDF]
, 2006 Identifies potential programs for the Mental Health Services Act, enacted in November 2004. Outlines three types of family and community based treatment models and provides recommendations for implementing each ...
core
PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe
Advanced Science, EarlyView.This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao +14 more
wiley +1 more source
Parent and Family Outcomes of PEERS: A Social Skills Intervention for Adolescents with Autism Spectrum Disorder [PDF]
, 2015 Raising a child with an Autism Spectrum Disorder (ASD) is associated with increased family chaos and parent distress. Successful long-term treatment outcomes are dependent on healthy systemic functioning, but the family impact of treatment is rarely ...
Carson, Audrey M. +5 more
core +1 more source
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
BMC PsychologyBackground Children with learning disabilities often face challenges in academic performance, particularly in reading. Parent-child play therapy has emerged as a potential intervention to address these challenges by fostering a supportive learning ...
Tian Xu
doaj +1 more source
Engulfed by the Spectrum: The Impact of Autism Spectrum Disorders on Law and Policy [PDF]
, 2011 The recent increased awareness of Autism Spectral Disorders (“ASD”) has led to rapid development in laws meant to ensure disabled children receive adequate treatment and education. This development is due in large part to the proliferation of litigation
Bennett, Emily, Dicker, Sheryl
core +2 more sources