Results 191 to 200 of about 230,725 (258)

Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution

open access: yesAngewandte Chemie International Edition, EarlyView.
Novel and biocompatible photoactivatable oxytocin and vasopressin probes, utilising state‐of‐the‐art photocages, remain inactive in the dark. Light exposure facilitates rapid spatiotemporal receptor activation and phospholipase C (PLC)‐mediated downstream signalling. Figure created in https://BioRender.com.
Konstantin Raabe   +7 more
wiley   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

open access: yesAngewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne   +22 more
wiley   +1 more source

Keeping an "I" on PRIDE: Measuring Imitation in Parent-Child Interaction Therapy. [PDF]

open access: yesBehav Ther, 2021
McCabe KM   +6 more
europepmc   +1 more source

Feasibility of Digital Augmentation of Parent-Child Interaction Therapy: A Randomized Clinical Trial.

open access: yesJAMA Netw Open
Romanowicz M   +14 more
europepmc   +1 more source

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