Results 81 to 90 of about 230,967 (299)

Early Pathways Therapy for Young Children in Poverty: A Randomized Controlled Trial [PDF]

open access: yes, 2015
Early Pathways is a home-based, parent and child therapy program for the treatment of disruptive behaviors among young children living in poverty. In this study, 199 clinically referred children were randomly assigned to an immediate treatment (IT) or ...
Fox, Robert A.   +2 more
core   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

open access: yesAdvanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang   +14 more
wiley   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

open access: yesAdvanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li   +7 more
wiley   +1 more source

The Child Silenced by Social Anxiety [PDF]

open access: yes, 2012
This meta-synthesis explores the subject of selective mutism across multiple age groups. Selective mutism is present in a very small percentage of students.
Merrill, Kellie
core  

Desenho em série com meninas que apresentam comportamento oposicionista desafiante em sala de aula [PDF]

open access: yes, 2015
Este estudio investigó las correlaciones entre la participación en sesiones terapéuticas de dibujo en serie, no dirigido, y la presencia o ausencia de mejoría en el comportamiento oposicionista desafiante (COD) de cinco niñas, de ocho a diez años de edad,
Boone-Salles, Andréia Mansk
core   +2 more sources

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

open access: yesAdvanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li   +11 more
wiley   +1 more source

Parent-Child Interaction Therapy in a Case of Global Developmental Delay and Leukoencephalopathy

open access: yesFrontiers in Psychiatry, 2018
Parent-child interaction therapy (PCIT) is an evidence-based, behavioral dyadic treatment for caregivers and their children aged 2–7 years old with emotional and behavioral disorders.
Reem M.A. Shafi   +3 more
doaj   +1 more source

Feasibility, Acceptability, and Preliminary Outcomes of a Culturally Adapted Evidence-Based Treatment for Latino Youth With ADHD [PDF]

open access: yes, 2019
Objective: To advance our knowledge about the most effective way to treat Latino youth with ADHD, the current feasibility and pilot study compared a culturally adapted evidence-based treatment (CAT) for ADHD to standard evidence-based treatment (EBT ...
Castro, Al   +3 more
core   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

open access: yesAdvanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim   +11 more
wiley   +1 more source

Cooperative parent mediated therapy for Italian children with autism spectrum disorder: a clinical experimental study in a community healthcare service in Italy

open access: yesFrontiers in Child and Adolescent Psychiatry
IntroductionThis Clinical Experimental Study aimed to evaluate the effectiveness of Cooperative Parent Mediated therapy (CPMT), a targeted parent-coaching program for Autism Spectrum Disorder (ASD), in Community Healthcare Service in Italy.MethodsForty ...
Alessandra Carta   +11 more
doaj   +1 more source

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