Results 71 to 80 of about 1,443,788 (321)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Demographic Changes and Parent–Child Relationships [PDF]
Parenting, 2006 This tutorial describes demographic changes and their implications for parenting and parent–child relationships. First, we discuss 2 major sociodemographic changes—declining fertility and increasing longevity—from the point of view of social demography.
Trommsdorff, Gisela, Nauck, Bernhard
openaire +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Post-divorce parental conflict, maternal economic hardship, parent-child relationship and academic achievement among adolescents in divorced families [PDF]
, 2013 The purpose of this study was to determine the relationships between post-divorce parental conflict, maternal economic hardship and parent-child relationship with academic achievement in a sample of 800 adolescents of divorced families aged 15to 18 years
Esmaeili, Nooshin Sabour +1 more
core
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Parent-Child Relationships and Mindfulness
Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 2012 Psychological approaches such as mindfulness-based stress reduction or mindfulness-based cognitive therapy could be effective for relieving a wide range of psychosocial stresses or frictions between parents and children. Several interventional approaches based on mindfulness have been shown to be useful for improving parent-child relationships not only
Kouichi, Yoshimasu +4 more
openaire +3 more sources
Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz +3 more
wiley +1 more source
The effect of family oriented problem solving curriculum education on parent-child relationship elementary School Students [PDF]
Faṣlnāmah-i Farhang Mushavirah va Ravān/Darmānī, 2016 The aim of present study was to determine of the effectiveness of family oriented problem solving education on parent-child relationship among students of elementary schools in Kermanshah city.
kivan kakabaraee
doaj +1 more source
Arthritis Care &Research, Accepted Article.Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy +9 more
wiley +1 more source
Developmental Psychology, 2019 Compassion is known to predict prosocial behavior and moral judgments related to harm. Despite the centrality of compassion to social life, factors predicting adulthood compassion are largely unknown.
M. Hintsanen +9 more
semanticscholar +1 more source