Results 131 to 140 of about 1,118,166 (301)

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

open access: yesAdvanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie   +7 more
wiley   +1 more source

Development and Testing of an Anxiety Model in Elementary School Students Based on Executive Functions and the Parent/Child Relationship: Mediating Role of Emotion Regulation [PDF]

open access: yesIranian Journal of Educational Research
Objective: This study aimed to develop and test a model of anxiety in elementary school students based on executive functions and the parent-child relationship, considering the mediating role of emotion regulation.
Salar Mohamadi Bolbanabad   +2 more
doaj  

Welfare Reform and Lone Parents in the UK [PDF]

open access: yes
The last thirty years saw dramatic increases in the proportion of children living in lone parent households. In 1997 the incoming Labour government initiated a series of policy reforms aimed at reducing this high level of child poverty.
Paul Gregg, Sarah Smith, Susan Harkness
core  

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

open access: yesAdvanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel   +16 more
wiley   +1 more source

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu   +6 more
wiley   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu   +9 more
wiley   +1 more source

Families and Economic Mobility [PDF]

open access: yes, 2008
Surveys the literature on the effect of family structure, socioeconomic status, childrearing practices, and transmission of parental traits on academic success and mobility.
Jessica Kronstadt, Melissa Favreault
core  

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

open access: yesAdvanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou   +22 more
wiley   +1 more source

Perception Differences between Families and Teachers on the Integral Development of the Child and the Educational Process

open access: yesEducation Sciences
Educational development should be balanced among the different agents that make-up the entirety of the educational community (students, teachers, families, and external agents), with a prominent role of the family and teachers.
Enrique Muñoz-Herrera   +3 more
doaj   +1 more source

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