Results 151 to 160 of about 1,115,203 (281)
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced Science, EarlyView.Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source
Advanced Science, EarlyView.This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu +10 more
wiley +1 more source
HUBUNGAN ANTARA KONSEP DIRI DAN POLA ASUH ORANG TUA DENGAN KONFORMITAS SANTRI
Jurnal Penelitian Humaniora, 2013 This research aims to identify the relationship between self concept and parent nurturing pattern and santri (Islamic boarding school students) conformity.
Awaludin Mufti Efendi
doaj
Welfare Reform and Lone Parents in the UK [PDF]
The last thirty years saw dramatic increases in the proportion of children living in lone parent households. In 1997 the incoming Labour government initiated a series of policy reforms aimed at reducing this high level of child poverty.
Paul Gregg, Sarah Smith, Susan Harkness
core
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging
Advanced Science, EarlyView.Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen +3 more
wiley +1 more source
Parental burnout as a challenge for the parent-school partnership
Multidisciplinary Journal of School EducationResearch objectives (aims) and problems: This article analyzes the parent-school partnership in the context of parental burnout (PB). PB is a syndrome characterized by parents’ exhaustion resulting from prolonged stress and a chronic imbalance between ...
Lidia Wiśniewska-Nogaj
doaj
Parents-school relationships. the case of Chinese children in French Immersion in Vancouver, BC
, 2009 This study explores the relationship between minority language parents and schools. The research was conducted through semi-structured interviews with the parents to collect their thoughts and preferences in regards to their experiences and involvement at their children’s schools as well as their perspective on the inclusion of their culture and ...
openaire +1 more source
Advanced Science, EarlyView.ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao +14 more
wiley +1 more source
Advanced Science, EarlyView.A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley +1 more source