Results 81 to 90 of about 3,096,886 (286)
BMC Medical Research Methodology, 2019 Background Muscular dystrophies (MDs) are a group of inherited conditions characterized by progressive muscle degeneration and weakness. The rarity and heterogeneity of the population with MD have hindered therapeutic developments as well as ...
Xiaoxue Chen +4 more
doaj +1 more source
Wages and Mobility: The Impact of Employer-Provided Training [PDF]
Using data from the National Longitudinal Survey of Youth (NLSY) for the period spanning the years 1979-1991, this essay examines the impact of employer-provided formal training on the wage profile and on the mobility of young Americans making their ...
Daniel Parent
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Clinical Epigenetics, 2019 Background Children prenatally exposed to maternal depression more often show behavioral and emotional problems compared to unexposed children, possibly through epigenetic alterations.
Laura S. Bleker +8 more
doaj +1 more source
The Time of the Infant, Parent-Infant Desynchronization and Attachment Disorganization, or How Long Does it Take for a Preventive Action to be Effective? [PDF]
The classical version of early development by psychoanalysis has been largely challenged by developmental psychology, and particularly by attachment theory.
Antoine Guedeney +7 more
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Will Parent Training Reduce Abuse, Enhance Development, and Save Money? Let's Find Out [PDF]
, 2009 Outlines a strategy for testing the feasibility of community-developed parent training initiatives to prevent child abuse and neglect. Calls for a federal grant program to test community-wide implementation of parent training programs in ...
Richard P. Barth, Ron Haskins
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Open Education StudiesSince the expansion of higher education began, student motivation and institutional choice have been widely studied, yet the reasons behind high dropout rates in public institutions in Central and Eastern Europe remain poorly understood. In our research,
Pusztai Gabriella +2 more
doaj +1 more source
Patient’s experiences with the care for juvenile idiopathic arthritis across Europe
Pediatric Rheumatology Online Journal, 2018 Background To assess the views of juvenile idiopathic arthritis (JIA) patients and their parents on the care and treatment they receive in referral pediatric rheumatology centers throughout Europe.
E. H. Pieter. van Dijkhuizen +11 more
doaj +1 more source