Results 71 to 80 of about 1,328,628 (304)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Identification of Trace Organic Components in the CR Chondrites by 4D TOFMS [PDF]

, 2007
This paper reports preliminary results of a 4D TOFMS study of CR chondrite organic material, highlighting the low-level organic species that may further reveal the complexity of parent body modification of interstellar ...
Gilmour, I., Morgan, G. H., Pearson, V. K., Perronnet, M., Turner, D.   +4 more
core  

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Overview of Mars: SNC meteorite results [PDF]

The SNC meteorites according to their oxygen isotope ratios and various trace element ratios form a distinct group of 8 achondrites. Their young crystallization ages and fractionated REE pattern which exclude an asteroidal origin, were the first ...
Waenke, H.
core   +1 more source

Oxygen isotopic and petrological constraints on the origin and relationship of IIE iron meteorites and H chondrites [PDF]

, 2011
New oxygen isotopic measurements of IIEs and H chondrites are indistinguishable — strengthening a possible common origin for these groups.
Anand, M., Franchi, I. A., Greenwood, R. C., Mcdermott, K., Scott, E. R. D.   +4 more
core  

Early evolution of disrupted asteroid P/2016 G1 (PANSTARRS) [PDF]

, 2016
We present deep imaging observations of activated asteroid P/2016 G1 (PANSTARRS) using the 10.4m Gran Telescopio Canarias (GTC) from late April to early June 2016.
Cabrera-Lavers, Antonio, Licandro, Javier, Moreno, Fernando, Pozuelos, Francisco J.   +3 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

“CY1” Chondrites Produced by Impact Dehydration of the CI Chondrite Parent Body

The Astrophysical Journal Letters
The recently proposed Yamato-type (CY) chondrites share significant similarities with CI chondrites and Ryugu. We present major and trace elemental, Re–Os, and mass-independent Ti, Cr, and Fe isotope data for seven CY chondrites. The elemental data along
Ke Zhu, Nao Nakanishi, Jan Render, Quinn R. Shollenberger, Tetsuya Yokoyama, Akira Ishikawa, Lu Chen   +6 more
doaj   +1 more source

Reflectance spectra of Mesosiderites: Implications for asteroid 4 Vesta [PDF]

, 2007
Oxygen isotopic data argues that HEDs and mesosiderites may be from the same parent body. A spectral survey of mesosiderites was done to determine their spectral properties in the visible and near-infrared and compare to ...
Buchanan, P.C., Burbine, T.H., Franchi, I.A., Greenwood, R.C., Smith, C.L.   +4 more
core