Results 111 to 120 of about 855,376 (285)

Parent–child attachment and adolescent problematic behavior: the mediating effect of legal emotions

open access: yesFrontiers in Psychology
IntroductionIn criminology, the close relationship between legal emotions and adolescent deviant behavior is well-documented. In psychology, parental attachment is strongly associated with children’s problematic behavior; however, the role of legal ...
He Jianhua, Xu Su, Xu Shuhui
doaj   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

open access: yesAdvanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang   +11 more
wiley   +1 more source

Parental attachment, smartphone addiction and stress among undergraduate students

open access: yes, 2019
This study aims to determine the relationships between parental attachment, smartphone addiction and stress among undergraduate students. By using a multi-stage cluster random sampling technique, a total of 400 respondents were involved in this study ...
Tan, Pey Shyan, Arshat, Zarinah
core   +2 more sources

A Versatile DNA‐Encoded Library Platform for the Discovery of Highly Cooperative Chemical Inducers of Proximity

open access: yesAdvanced Science, EarlyView.
We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong   +11 more
wiley   +1 more source

Adult Attachment as Moderating Variable for Parental Burnout [PDF]

open access: yes
In recent years, research in family sciences has focused on the impact of stress on parents, leading to parental burnout risks. This study aimed to explore how adult attachment relates to parental burnout and if it moderates the link between parenting ...
McCann, Janell
core  

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

open access: yesAdvanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu   +10 more
wiley   +1 more source

Exploring the Role of Attachment Styles, Life Scripts, and Parental Mandates in Suicidal Behavior: Implications for Prevention and Intervention

open access: yesEuropean Psychiatry
Introduction The scientific literature widely acknowledges the multitude of factors contributing to suicide, emphasizing the intricate and dynamic interplay among genetic, biological, psychological, and social dimensions (Van Heeringen, 2001).
A. Romero Otalvaro   +2 more
doaj   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

open access: yesAdvanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia   +8 more
wiley   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

open access: yesAdvanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang   +9 more
wiley   +1 more source

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