Results 71 to 80 of about 5,666,140 (279)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Parental Involvement on Children's Educational Achievement: A Scoping Review

International Journal on Studies in Education
Parental involvement is vital in developing individual empowerment and improving the community through education. The scoping review investigates the various kinds and intensities of parental involvement and how they affect children's learning results in
Yammuna Sivabalan, Lim Seong Pek, Na-Thinamalar Magiswary Nadarajan, Hafizah Kusnek Khusni, Rita Wong Mee Mee, Md Rosli Ismail   +5 more
doaj   +1 more source

The Significance of Parental Involvement in the Development in Infancy

Journal of Educational Research and Practice, 2020
The earliest years’ experiences of children can ensure their future success, and parenting is noted to be an influential factor (Bronfenbrenner, 1979; Lamb et al., 2002).
Yanhui Liu, M. F. Sulaimani, J. Henning
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Mission Possible? Institutional Family-School-Community Partnership Practices and Parental Involvement in Hungarian Majority and Minority Schools in Three Central and Eastern European Countries

Social Sciences
Decades of research suggest that higher levels of parental education are related to more active and effective parental involvement (PI) practices. At the same time, schools’ policies and practices facilitate family-school-community partnerships (FSCPs ...
Gabriella Pusztai, Katinka Bacskai, Tímea Ceglédi, Zsófia Kocsis, Megumi G. Hine   +4 more
doaj   +1 more source

Parental participation improves student academic achievement: A case of Iganga and Mayuge districts in Uganda

Cogent Education, 2016
Educational research has linked parental participation in children’s schooling with a wide range of children’s academic outcomes. Parental involvement involves time and resource commitment towards children’s academic performance. This paper extracts data
G.M. Mahuro, N. Hungi
doaj   +1 more source

Parental involvement and children’s enjoyment in sport

Qualitative Research in Sport, Exercise and Health, 2020
The purpose of this study was two-fold: 1) to examine children’s preferences for parental involvement that enhances their enjoyment in sport, and; 2) to identify the factors that facilitate or prevent parents from being involved in the ways preferred by ...
Maita G. Furusa, Camilla J. Knight, D. Hill   +2 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Advancing the study of parental involvement to optimise the psychosocial development and experiences of young athletes

Psychology of Sport And Exercise, 2019
The purpose of this article is to review and critique the literature in youth sport that specifically relates to parental influence on the experiences and psychosocial development of young athletes.
C. Harwood, Camilla J. Knight, S. Thrower, Steffan R. Berrow   +3 more
semanticscholar   +1 more source