Results 51 to 60 of about 155,370 (254)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Mission Possible? Institutional Family-School-Community Partnership Practices and Parental Involvement in Hungarian Majority and Minority Schools in Three Central and Eastern European Countries

Social Sciences
Decades of research suggest that higher levels of parental education are related to more active and effective parental involvement (PI) practices. At the same time, schools’ policies and practices facilitate family-school-community partnerships (FSCPs ...
Gabriella Pusztai, Katinka Bacskai, Tímea Ceglédi, Zsófia Kocsis, Megumi G. Hine   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Parental participation improves student academic achievement: A case of Iganga and Mayuge districts in Uganda

Cogent Education, 2016
Educational research has linked parental participation in children’s schooling with a wide range of children’s academic outcomes. Parental involvement involves time and resource commitment towards children’s academic performance. This paper extracts data
G.M. Mahuro, N. Hungi
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Profiles of Parental Home-Based Involvement: Associations with Preschool Children’s Positive Psychological Traits and Social Adaptation

Psychology Research and Behavior Management
Keman Yuan, Weiqi Liang, Jiaxin Sun, Jingyao Wang, Yan LiShanghai Institute of Early Childhood Education, Shanghai Normal University, Shanghai, 200234, People’s Republic of ChinaCorrespondence: Yan Li, Shanghai Institute of Early Childhood Education ...
Yuan K, Liang W, Sun J, Wang J, Li Y
doaj  

From Their Perspective: Parental Involvement in the UAE

International Journal of Sociology of Education, 2013
The purpose of this paper is to share findings from a mixed-method study that explores, from the perspective of Emirati parents, what it means to be involved in their children’s education.
Jase Moussa-Inaty, Esperanza De La Vega
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Understanding the moderators of parental involvement in the early schooling of children in neoliberal and multicultural societies

International Journal of Educational Research Open
It is widely acknowledged that early childhood education is vital to children's success in later years. However, there is a limited exploration of parental involvement in early school education.
Shaikha Saeed, Negmeldin Alsheikh, Najwa Alhosani, Maxwell Peprah Opoku, Hala Elhoweris   +4 more
doaj   +1 more source