Results 51 to 60 of about 171,851 (293)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Parental Involvement and Students Academic Outcome: Exploring the Mediating Role of Academic Motivation

open access: yesThe Sky
The research is aimed to determine the influence of mediating variable academic motivation in relationship between parental involvement and academic outcomes (dropout/pass) partially and complementarily among intermediate 1st year students. Additionally,
Sardar Nasir Sohail Khan   +2 more
doaj   +1 more source

Examining the connections between teacher self-efficacy and parental involvement practices [PDF]

open access: yesSpecijalna Edukacija i Rehabilitacija
Introduction. Teacher self-efficacy and parental involvement are closely connected and can both have a significant impact on student success. Objectives.
Chliara Panagiota V.   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Parental engagement: a study into the involvement of parents of early years' children [PDF]

open access: yes, 2008
This study examines the use of parental involvement within early years area based initiatives designed to 'raise standards, widen participation and promote social inclusion'. The imperative to involve parents in communities labelled as 'disadvantaged' is
McKenna, Lynne
core  

Leadership Practices that Support Parental Involvement in One High Needs Elementary School

open access: yes, 2017
Research has continually supported the idea that increased levels of parental involvement in educational settings have a positive effect on student outcomes across racial, socioeconomic, and cultural lines.
Savage, Brett C
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The Mediating Effect of Teacher Support on the Relationship Between Parental Involvement and Student Academic Productivity

open access: yesInternational Journal of Multidisciplinary Educational Research and Innovation
This study aims to determine the mediating effect of teacher support regarding the relationship between parental involvement and student academic productivity; identify the level of parental involvement, teacher support, and student academic productivity
Ruel Jr. B. Cacanando   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Factors affecting early childhood educators’ views and practices of parental involvement

open access: yesJournal of Early Childhood Education Research, 2018
Past research has shown the significant role of parental involvement in children’s academic achievements as well as their healthy development and well-being. For effective parental involvement, it is imperative to understand the views of early childhood
Sevcan Hakyemez-Paul   +2 more
doaj  

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