Results 101 to 110 of about 137,241 (299)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

The Role of Acculturation Differences and Acculturation Conflict in Latino Family Mental Health [PDF]

open access: yes, 2018
In order to help address the mental health disparities that exist for Latino families in the U.S., the current study sought to examine the acculturation–mental health link within the context of Latino families and to identify potential mechanisms for ...
Gerdes, Alyson C.   +2 more
core   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

open access: yesFEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Parenting in the Digital Age: Mediation Strategies as a Preventive Factor against Cyberbullying on Social Media among Saudi Parents

open access: yesCommunication & Society (Formerly Comunicación y Sociedad)
This study investigated the role of parental mediation strategies employed by parents in Saudi Arabia as a preventive factor against adolescents’ engagement in cyberbullying and cybervictimization within social media.
Maisoon-Osama Alsebaei   +1 more
doaj   +1 more source

Parental rearing style as a predictor of attachment and psychosocial adjustment during young adulthood [PDF]

open access: yes, 2012
Parental rearing-styles are crucial for psychosocial adjustment both during childhood and adulthood. The current study examined whether: (a) parental rearing-styles predicted psychosocial adjustment in young-adulthood, (b) this relationship was mediated ...
Betts, LR   +4 more
core   +1 more source

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

A “Principled Resolution”: The Fulcrum for Bioethics Mediation [PDF]

open access: yes, 1994
The concept of a principled resolution is the foundation for bioethics mediation. Dubler presents the core bioethical principles that support the creation of principled resolutions as fulcrums for resolving disagreements in the healthcare setting ...
Dubler, Nancy Neveloff
core   +2 more sources

Parenting Practices, Life Satisfaction, and the Role of Self-Esteem in Adolescents [PDF]

open access: yes, 2019
Introduction: Studies have shown significant associations between parenting practices, life satisfaction, and self-esteem, and the role of parenting practices in adolescent adjustment, emphasizing its influence on wellbeing.
Atienza   +26 more
core   +2 more sources

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