Results 91 to 100 of about 29,368 (292)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

An examination of parental knowledge of adolescent media consumption and parental mediation. [PDF]

, 2001
Overall, the results revealed that parents are generally knowledgeable about the types and quantity of media their adolescents' use. Furthermore, parents may try to employ parental mediation strategies, but may not be effective in their communication of ...
Mazur, Michelle Ann.
core  

Influence of Co-Parenting on Parental Burnout: A Moderated Mediation Model

Behavioral Sciences
Adolescence has always been regarded as a period of rapid psychological and behavioral change. Adolescents are subject to more difficult behaviors, and those difficult behaviors have a great impact on co-parenting and parenting burnout. In order to reveal the relationship between these factors, this study investigated the mediating effect of difficult ...
Zhang, Qin, Zhao, Mei
openaire   +4 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Parenting in the Digital Age: Mediation Strategies as a Preventive Factor against Cyberbullying on Social Media among Saudi Parents

Communication & Society (Formerly Comunicación y Sociedad)
This study investigated the role of parental mediation strategies employed by parents in Saudi Arabia as a preventive factor against adolescents’ engagement in cyberbullying and cybervictimization within social media.
Maisoon-Osama Alsebaei, Shuaa Abdulrahman Aljasir   +1 more
doaj   +1 more source

Co-Parenting and Parental Involvement in Chinese Families: Parenting Competence as a Mediator

Journal of Family Issues
Co-parenting is linked to parental involvement in children’s learning activities, yet the mechanisms and interdependence between mother-father dyads remain unclear. Drawing on 251 Chinese mother-father dyads of preschoolers, this study examined the direct effects of mother- and father-reported co-parenting quality on parental involvement in children’s ...
Jiayin Zheng, Lixin Ren
openaire   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Parental Internet Mediation: A Phenomenological Study [PDF]

Parental Internet mediation, which is the strategies parents use to control and supervise online content for children, has been transformed into a critical role due to the mixed outcomes of digital use.
Marino-Vega, Jossie
core   +1 more source

Parental Mediation of Adolescent Movie Viewing [PDF]

, 2014
Parental mediation of media use by children has been studied extensively as it applies to television and children 12 years old and younger. This study expands the scope of Parental Mediation Theory by applying it to adolescents (age 13-17 years old) and ...
Webster, Larry James, Jr.
core   +1 more source