Results 71 to 80 of about 29,368 (292)

Does parental media mediation make a difference for adolescents? Evidence from an empirical cohort study of parent-adolescent dyads

open access: yesHeliyon, 2023
Background and aims: Adolescents, who are undergoing brain changes, are vulnerable to many online risks in their use or overuse of digital technology. Parental media mediation (a set of practices parents use to guide children's media use and to reduce ...
Shunsen Huang   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Growth-Promoting Parental Mediation Scale The Effect of Positive Parental Mediation on Children’s Experienced [PDF]

open access: yes, 2018
The aim of this experimental study was to examine if children can experience meaningfulness after watching a meaningful movie and whether positive parental mediation can increase this effect. This experiment involves 82 children (M = 10.83; SD = 1.098)
Hoed, den L.
core  

Surveying Parental Mediation: Connections, Challenges and Questions for Media Literacy [PDF]

open access: yes, 2013
This paper examines three strategies of parental mediation—coviewing, restrictive mediation, and active mediation—in order to make connections, challenge, and raise questions for media literacy.
Mendoza, Kelly
core   +2 more sources

Parental rearing as a mediator of the relationship between parents and children [PDF]

open access: yese-Pedagogium, 2017
Cieľ: Prioritou pre nas pri voľbe metodiky sa stal vzťah medzi rodicom a dieťaťom. Jednou z tez, ktore nas viedli bola bezpecna vzťahova vazba medzi vzťahovými osobami, v nasom pripade medzi rodicmi a deťmi. Zamerali sme sa na dospelých jedincov (nositeľov bezpecnej vzťahovej vazby) ako na buducich mediatorov vzťahov so svojimi potomkami.
openaire   +1 more source

Parental Cognitive Errors Mediate Parental Psychopathology and Ratings of Child Inattention [PDF]

open access: yesFamily Process, 2016
We investigate the Depression‐Distortion Hypothesis in a sample of 199 school‐aged children with ADHD‐Predominantly Inattentive presentation (ADHD‐I) by examining relations and cross‐sectional mediational pathways between parental characteristics (i.e., levels of parental depressive and ADHD symptoms) and parental ratings of child problem behavior ...
Haack, Lauren M   +6 more
openaire   +4 more sources

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Parental mediation of the internet in Singapore. [PDF]

open access: yes, 2011
The study examined how parental mediation of adolescents’ Internet use can be affected by key antecedents such as family communication patterns (FCPs), parents’ perceived online literacy, parents’ perception of the Internet and socio-demographic factors ...
Ng, Zhong Ming.   +3 more
core  

Parental mediation of smartphone and social media activities to protect early adolescent children from online risks

open access: yesInternational Journal of Adolescence and Youth
Early adolescent children engage in Internet-based online activities on smartphones and social media, which may result in online risks, including sexual risks.
Kendra Allison, Robin M. Dawson
doaj   +1 more source

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