Results 61 to 70 of about 737,256 (284)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mediation and peace [PDF]

, 2010
This paper applies mechanism design to conflict resolution. We determine when and how unmediated communication and mediation reduce the ex ante probability of conflict in a game with asymmetric information.
Hörner, Johannes, Francesco Squintani, Morelli, Massimo, HOERNER, Johannes, Johannes Hörner, Squintani, Francesco, Massimo Morelli   +6 more
core   +2 more sources

The role of parental control apps and parental knowledge in adolescents' sleep-related screen use: A nationwide study

Computers in Human Behavior Reports
Background: Previous studies have shown significant associations between screen-based device (SBD) use and adverse sleep outcomes among children and adolescents.
Zsolt Horváth, Julia Tibot, Orsolya Király, Shu M. Yu, Borbála Paksi, Andrea Eisinger, Mark D. Griffiths, Beáta Bőthe, Marco Zavagni, Helen Carter, Lorena Soler Casale, Keri Scott, Jackie Linares, Zsolt Demetrovics, Andrea Czakó   +14 more
doaj   +1 more source

Parental rearing as a mediator of the relationship between parents and children [PDF]

e-Pedagogium, 2017
Cieľ: Prioritou pre nas pri voľbe metodiky sa stal vzťah medzi rodicom a dieťaťom. Jednou z tez, ktore nas viedli bola bezpecna vzťahova vazba medzi vzťahovými osobami, v nasom pripade medzi rodicmi a deťmi. Zamerali sme sa na dospelých jedincov (nositeľov bezpecnej vzťahovej vazby) ako na buducich mediatorov vzťahov so svojimi potomkami.
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Peran Mediasi Orang Tua dan Anonimitas terhadap Kecenderungan Cyberbullying Siswa

Jurnal Psikologi, 2019
This study aims to determine the role of parental mediation and anonymity towards the tendency of cyberbullying behavior of high school students. This research needs to be done because the tendency of cyberbullying among students is increasing lately. In
Fauzan Heru Santhoso
doaj   +1 more source

Parental Cognitive Errors Mediate Parental Psychopathology and Ratings of Child Inattention [PDF]

Family Process, 2016
We investigate the Depression‐Distortion Hypothesis in a sample of 199 school‐aged children with ADHD‐Predominantly Inattentive presentation (ADHD‐I) by examining relations and cross‐sectional mediational pathways between parental characteristics (i.e., levels of parental depressive and ADHD symptoms) and parental ratings of child problem behavior ...
Haack, Lauren M, Jiang, Yuan, Delucchi, Kevin, Kaiser, Nina, McBurnett, Keith, Hinshaw, Stephen, Pfiffner, Linda   +6 more
openaire   +4 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Parental mediation of smartphone and social media activities to protect early adolescent children from online risks

International Journal of Adolescence and Youth
Early adolescent children engage in Internet-based online activities on smartphones and social media, which may result in online risks, including sexual risks.
Kendra Allison, Robin M. Dawson
doaj   +1 more source