Results 51 to 60 of about 737,256 (284)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Surveying Parental Mediation: Connections, Challenges and Questions for Media Literacy
Journal of Media Literacy Education, 2013 This paper examines three strategies of parental mediation—coviewing, restrictive mediation, and active mediation—in order to make connections, challenge, and raise questions for media literacy.
Kelly Mendoza
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Music and parental wellbeing: A position paper [PDF]
This article sets out a collective vision for a new Music and Parental Wellbeing Alliance. It starts from the premise that challenges to parental wellbeing represent a persistent, global concern.
The Music and Parental Wellbeing Research Network +1 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
BMC Public Health, 2023 Background Since children can only control and limit their own media use to a limited extent, it is often the parents who regulate their children’s media use.
Tanja Poulain +3 more
doaj +1 more source
Parenting Styles and Parent–Adolescent Relationships: The Mediating Roles of Behavioral Autonomy and Parental Authority [PDF]
Frontiers in Psychology, 2018 The parent-adolescent relationship has been a classic research topic, and researchers have found that parenting styles (e.g., authoritative, authoritarian) are closely related to various qualities of parent-adolescent relationships (e.g., cohesion, conflict).
Xinwen Bi +5 more
openaire +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Social Media + Society, 2021 This study examined the moderating and mediating variables in parental mediation practices in Nigerian families in the digital age. This study applied a multi-stage sampling technique to achieve an adequate representation of the population in six ...
Ifeanyi Adigwe
doaj +1 more source
Qualitative Sociology Review, 2022 Research on parental mediation of children’s online engagements situate historically longstanding anxieties within the dynamics of present-day information communications technologies (i.e., concerns over new “cyber risks,” as well as opportunities).
Michael Adorjan +2 more
openaire +5 more sources