Results 61 to 70 of about 147,663 (307)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Parental participation in primary education [PDF]

open access: yes
This thesis is a qualitative study of the power relations structuring interactions between parents and teachers in one inner London borough. The first three chapters consider the theories and practice of participation and the extent of its realisation
Vincent, Carol
core  

Parental participation: overall survey findings

open access: yes, 2018
The Prevention, Partnership and Family Support (PPFS) Programme is a comprehensive programme of early intervention and preventative work which is being undertaken by Tusla, Ireland’s Child and Family Agency, with the support of the UNESCO Child and ...
Crosse, Rosemary, Devaney, Carmel
core   +1 more source

Parental Stress, Depression, Anxiety, and Participation in Neonatal Care in a Referral Brazilian NICU over Different Phases of the COVID-19 Pandemic

open access: yesChildren
Background/Objectives: During the COVID-19 pandemic, neonatal care units had to change protocols, and little is known about its impact on parents’ mental health.
Dafne Barcala Gomez   +13 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Fathers' childcare and parental leave policies: Evidence from Western European Countries and Canada [PDF]

open access: yes
The study at hand pursues the following question: How are national parental leave arrangements related to fathers' participation in and time used for childcare?
Reich, Nora   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Labour Market Effects of Parental Leave: A European Perspective [PDF]

open access: yes
We investigate the aggregate-level effects of parental leave legislation on various labour market outcomes of women in 16 European countries for the period since 1970. The paper updates and extends previous findings in the literature.
Janneke Plantenga, Yusuf Emre Akgunduz
core  

Analysis of Factors Affecting Parental Participation Towards Early Childhood Education Program

open access: yesJournal of Nonformal Education, 2019
The lack number of teachers in Wonogiri district urgea participation between parents and organizer of Early Childhood Education (ECE) program. Related to this issue, this study aimed at (1) knowing the implementation of ECE program in Wonogiri district ...
Anik Tri Kustiani, Puji Yanti Fauziyah
doaj   +1 more source

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