Results 81 to 90 of about 590,638 (307)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The Determinants of Higher Education Participation in Ireland: A Micro Analysis [PDF]

open access: yes
In this paper we present a theoretical model of higher education participation in Ireland. Utilising the Living in Ireland Survey data we model the impact of costs (direct and indirect), the estimated life cycle returns, environmental and parental ...
Flannery, Darragh, O'Donoghue, Cathal
core  

Patterns in participation: Factors influencing parent attendance at two, centre-based early childhood interventions [PDF]

open access: yes, 2018
Interventions training parents of at-risk children have received considerable empirical support but their effectiveness is undermined by low attendance rates.
Boyle, Gemma   +6 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Parental Income and the Choice of Participation in University, Polytechnic or Employment at Age Eighteen: A Longitudinal Study [PDF]

open access: yes
This paper examines the link between parental income during adolescent years and higher education choices of the offspring at age 18. This study is the first to use a recent longitudinal data set from New Zealand (Christchurch Health and Development ...
Sholeh A. Maani
core  

Are the correlates of sport participation similar to those of screen time?

open access: yesPreventive Medicine Reports, 2015
Objective: To explore longitudinal and cross-sectional correlates of sport participation and screen time in a nationally representative sample of Australian children.
Mark S. Allen, Stewart A. Vella
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Labour Market Effects of Parental Leave: A European Perspective [PDF]

open access: yes
We investigate the aggregate-level effects of parental leave legislation on various labour market outcomes of women in 16 European countries for the period since 1970. The paper updates and extends previous findings in the literature.
Janneke Plantenga, Yusuf Emre Akgunduz
core  

Family support and ease of access link socio-economic status and sports club membership in adolescent girls : a mediation study [PDF]

open access: yes, 2013
Background Much research has been conducted into the determinants of physical activity (PA) participation among adolescent girls. However, the more specific question of what are the determinants of particular forms of PA participation, such as the link ...
Craike, Melinda J.   +4 more
core   +2 more sources

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