Results 91 to 100 of about 590,638 (307)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 1998 Altogether 2011 local school councils were approached in the GO, 520 participation councils in the VGO, and 219 participation councils in the OGO, divided proportionately over primary and secondary education. The response of'parents' representatives to the questionnaires that were sent wasfairly large.
Van Heddegem, Ilse, Verhoeven, Jef
openaire +1 more source
Education, Married Women¡¯s Participation Rate, Fertility and Economic Growth [PDF]
We construct a model, via educational expenditure, linking female labor supply to fertility and economic growth. Our paper includes three main themes. First, increases in parental time of teaching at home and educational expenditure lead to an increase ...
Hsiu-ling Yang
core
Perceived barriers to pediatrician and family practitioner participation in pediatric clinical trials: Findings from the Clinical Trials Transformation Initiative. [PDF]
, 2018 Despite legislation to stimulate pediatric drug development through clinical trials, enrolling children in trials continues to be challenging. Non-investigator (those who have never served as a clinical trial investigator) providers are essential to ...
Benjamin, Daniel K +12 more
core +2 more sources
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Labour supply incentives, income support systems and taxes in Sweden [PDF]
Comparing Sweden to other EU countries, labour force participation rates of older individuals and females are high. These facts are consistent with the idea that institutional design matters: access to child care, paid parental leave, and a tax system ...
Forslund, Anders
core
Journal of Sport and Health Science, 2017 Purpose: The objective of this study was to examine the associations between parental support for physical activity (PA) and levels of moderate-to-vigorous physical activity (MVPA) among Chinese school children.
Yang Liu +5 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Organized Sports, Overweight, and Physical Fitness in Primary School Children in Germany
Journal of Obesity, 2013 Physical inactivity is associated with poor physical fitness and increased body weight. This study examined the relationship between participation in organized sports and overweight as well as physical fitness in primary school children in southern ...
Clemens Drenowatz +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source