Results 61 to 70 of about 92,562 (256)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Abuse of parental rights: general characteristics, forms, and types
Bulletin of Kharkiv National University of Internal AffairsThe article is dedicated to the author’s perspective on the scientific and legislative resolution of the issue of abuse of parental rights. Special attention is given to the exploration of scientific approaches, national legislation, and judicial ...
O. G. Yushkevych
doaj +1 more source
We See This By The Father-Filial Responsibility
Yaşam Becerileri Psikoloji Dergisi, 2019 The inability of the adult person to be completely out of the parent's control should not be considered as an indicator of pathological dependence. The fact that a healthy adult individual is not able to fully comprehend his or her parent's authority is ...
Emine Er, Yener Ozen
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Parental Involvement with Children with Congenital Zika Virus Syndrome during the COVID-19 Pandemic [PDF]
Psicologia: Teoria e PesquisaThis qualitative, cross-sectional, multiple case study investigated parental involvement with children with Congenital Zika Virus Syndrome during the COVID-19 pandemic.
Amanda Schöffel Sehn +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Consent and parental responsibility - the past, the present and the future. [PDF]
Br Dent J, 2022 Keshtgar A, Hania M, Sharif MO.
europepmc +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Avoiding hypersensitive reluctance to address parental responsibility in childhood obesity. [PDF]
J Med Ethics, 2022 Feiring E +3 more
europepmc +1 more source