Results 231 to 240 of about 189,278 (307)

Pathogen‐Specific Bloodstream Infections Associated With Tumour Necrosis Factor‐α Inhibitors, Vedolizumab and Ustekinumab in Inflammatory Bowel Disease: A Danish Nationwide Case‐Control Study 2010–2024

Alimentary Pharmacology &Therapeutics, EarlyView.
In this nationwide study of patients with inflammatory bowel disease, TNF inhibitor use was associated with higher bloodstream infection rates, whereas vedolizumab and ustekinumab was not. Associations differed by pathogen species, and concomitant glucocorticoid use was associated with higher infection rates.
Cæcilie Leding, Alessandra Meddis, Jon Gitz Holler, Johan Burisch, Thomas Benfield   +4 more
wiley   +1 more source

Development and validation of an intelligent weight verification management system for neonatal ready-to-use parenteral nutrition infusions. [PDF]

PLoS One
Tang X, Zhu C, Cheng D, Zhu J, Qiu L, Han X, Feng C, Chen M.   +7 more
europepmc   +1 more source

Pharmacokinetics of tramadol and O‐desmethyltramadol in healthy dogs after a single oral dose of 2 mg/kg

Australian Veterinary Journal, EarlyView.
Tramadol exposure after low oral doses is variable in dogs, and the estimation of the terminal phase can be difficult when late concentrations plateau or rebound. This study characterized tramadol and O‐desmethyltramadol (M1) after a single oral dose of 2 mg/kg in 10 healthy female mixed‐breed dogs.
YDB Passos, NS Fernandes, KN Arcoverde, AN Mouta, R dos Anjos Honorato, G Araujo‐Silva, VV de Paula   +6 more
wiley   +1 more source

Rivaroxaban as Secondary Thromboprophylaxis in Pediatric Patients With Short Bowel Syndrome. [PDF]

Case Rep Hematol
Journell AF, Peters CE, Meznarich J, Goteti S.   +3 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Increased ureagenesis revealing metabolic intolerance to enhanced nutrition in the PICU: a secondary analysis of the PEPaNIC RCT. [PDF]

Crit Care
Vanhorebeek I, Umman Serin N, Verbruggen SCAT, Joosten KFM, Van den Berghe G, Gunst J.   +5 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Electrolyte supplementation patterns and evaluation in perioperative parenteral nutrition for patients undergoing major thoracoabdominal surgery: A multicenter, observational study. [PDF]

Medicine (Baltimore)
Huang Z, Jiang H, Zhu M, Gao C, Jia Z, Shen W, Huang H, Fan W, Liu S, Zhang S, Zhu L, He Y, Hou Z, Fan L, Hao C, Dai J, Li Z, Yuan T, Wang L, Chen L, Chen W.   +20 more
europepmc   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source