Results 51 to 60 of about 66,605 (262)

Effects of Irrational Parenthood Cognition, Family Support, and Resilience on Depression of Infertile Women [PDF]

open access: yesKorean Journal of Women Health Nursing, 2019
PURPOSE: To determine effects of irrational parenthood cognition, family support, and resilience on depression in infertile women. METHODS: Subjects were 118 infertile women who agreed to participate in this study.
Eun Young Cho, Mi Hae Sung
doaj   +1 more source

Life satisfaction and transition to parenthood [PDF]

open access: yes, 2014
A large of body of evidence reports an adverse effect of children on parental life satisfaction. Several alternative hypotheses have been proposed to explain this effect including after-birth changes in time schedules of both parents, in relationship ...
Bourton, Amelia   +2 more
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Anticipating Parenthood Among Lesbian, Gay, Bisexual, and Heterosexual Young Adults Without Children in Portugal: Predictors and Profiles

open access: yesFrontiers in Psychology, 2020
Parenthood is a highly valued life goal, independent of one’s sexual orientation. However, the majority of studies exploring young adults’ parenthood plans have relied exclusively on samples of heterosexual individuals.
Jorge Gato   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Ontological Choreography of (Good) Parenthood

open access: yes, 2016
The aim of this study is to unpack the notion of family togetherness as constitutive of good parenthood during visits to child cultural establishments like amusement parks, theme parks and children’s museums. The analyses challenge earlier assumptions of
Cardell, David   +7 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Original article The other side of the mirror – the role of partner’s empathy in transition to parenthood

open access: yesHealth Psychology Report, 2015
Background The general objective of the project was to verify the role the partner’s empathy plays in the perceived adjustment to parenthood. Couple empathy and especially partner’s perspective-taking have been linked to better adaptation to parenthood,
Maria Kaźmierczak   +2 more
doaj   +1 more source

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