Results 61 to 70 of about 1,026,850 (295)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dissociation as a mediator between perceived parental rearing style and depression in an adult community population using college students [PDF]

, 2007
The purpose of this study was to investigate the mediating process in the relationship between early parenting and depressive symptoms. In particular, the potential role of dissociation as a mediator between the perceived parental rearing style during ...
Murase, Satomi, Takai, Jiro, Yoshizumi, Takahiro, Murakami, Takashi   +3 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Comparison of Healthy and Unhealthy Perfectionism and Type A Personality in The Perceived Parenting Styles in University Students

فصلنامه خانواده پژوهی, 2016
The purpose of the present research is to study healthy and unhealthy perfectionism as well as type A personality based on different parenting styles.
مریم جهان بخش, ابوالقاسم خوش کنش, محمود حیدری   +2 more
doaj  

Parenting style, emotional intelligence, and social anxiety among adolescents: a systematic literature review [PDF]

This review set out to synthesize and analyze the existing research on the relation between parenting style, emotional intelligence (EI) and social anxiety among adolescents.
Ismail, Nellie, Gao, Yang, Arshat, Zarinah, Dahamat Azam, Mohamad Naqiuddin   +3 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Predictive Role of Emotional Intelligence and Perceived Parenting Styles in Happiness of Students [PDF]

پژوهشنامه روانشناسی مثبت, 2017
This study sought to determine the contribution of the variables of parenting style and emotional intelligence to happiness of high school students. The sample of the study was 345 students in Noorabad Mamasani, chosen through multi-stage random cluster ...
M Firoozi, M Mohammadi, F Nikdel
doaj   +1 more source

Measuring the impact and costs of a universal group based parenting programme : protocol and implementation of a trial [PDF]

, 2010
Background Sub-optimal parenting is a common risk factor for a wide range of negative health, social and educational outcomes. Most parenting programmes have been developed in the USA in the context of delinquency prevention for targeted or indicated ...
Anthony, Rebecca Elizabeth, Douglas E Simkiss, Thomas, Marie A., Wilson, L, Stallard, Nigel, Nigel Stallard, Stallard Nigel, Anthony, Becky, Stewart-Brown Sarah, Davies, Shan, Stallard, N, Helen Snooks, Stewart-Brown, Sarah, Simkiss, D.E, Rebecca Anthony, Lynsey Wilson, Anthony, B, Simkiss Douglas E, Stewart-Brown, Sarah L., Winstanley, Sarah, Wilson, Lynsey, Sarah Winstanley, Snooks, Helen A., Thomas Marie A, Snooks, Helen, Snooks Helen A, Marie A Thomas, Davies, S, Sarah Stewart-Brown, Winstanley Sarah, Wilson Lynsey, Davies Shan, Snooks, H.A, Winstanley, S, Stewart-Brown, S, Shan Davies, Helen A Snooks, Becky Anthony, Simkiss, Douglas E., Anthony Becky, Thomas, M   +40 more
core   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source