Results 101 to 110 of about 2,534,884 (308)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Landscape and Season Influence Bat Activity and Richness in a Mediterranean Metropolitan Area
Ecology and EvolutionUrbanisation alters landscapes and filters biodiversity, yet its effects in Mediterranean cities remain poorly understood despite their unique ecological and climatic context. As adaptable insectivores and key providers of ecosystem services, bats are an
Vincenzo Meola +4 more
doaj +1 more source
The Effect of Access to Waterbodies and Parks on Walking and Cycling in Urban Areas
InfrastructuresThis pilot study investigated whether good and bad access to waterbodies and parks have different impacts on walking and cycling in neighborhoods in urban areas.
Irene Sitohang +3 more
doaj +1 more source
Park dedication: press release
, 2015 This press release from the Department of the Interior and the National Park Service announces the events planned for the dedication of the Great Smoky Mountains National Park on Labor Day, September 2, 1940.
United States. Department of the Interior;
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Afet Sonrası Bir Kriz Yönetimi Bileşeni Olarak Kent Parkları; Malatya Örneği
Düzce University Faculty of Forestry Journal of ForestryAfetler sonucu doğal ve kültürel kaynakların süratle tükendiği günümüzde afet sonrası organizasyon çözümlemeleri önem taşıyan bir unsur haline gelmiştir. Bu noktada 6 Şubat depreminden etkilenen illerden biri olan Malatya ilinde belirlenen beş açık yeşil
Emine Deniz +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Stickers: Push the Appalachian National Park
, 2015 The Appalachian National Park Association carried out a wide-ranging promotional campaign throughout the eastern U.S. Within the first few months of its operation, the Association printed these colorful stickers with the motto, “Push the Appalachian ...
Appalachian National Park Association;
core