Results 131 to 140 of about 2,534,884 (308)
, 2015 This document, written in the summer of 1940, expresses the interest on behalf of President Franklin D. Roosevelt to be on hand to dedicate the Great Smoky Mountains National Park. The dedication did take place that year, on Labor Day, September 2, 1940.
United States. National Park Service;
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Appalachian National Park Association Newspaper Clippings, 1902-1907, 1925, 1928
, 2015 This is one of two notebooks assembled by the Appalachian National Park Association that includes documents and news clipping about the organization. The Appalachian National Park Association was formed in 1899 for the purpose of promoting the idea of a ...
Appalachian National Park Association;
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Requisition: Appalachian National Park Association
, 2015 This is a blank copy of a requisition form for ordering on behalf of the Appalachian National Park Association.Requisition No. On REQUISITION. No — Appalachian National Park Association* \ AH orders for printing or other supplies must be accompanied by
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FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
, 1991 Black and white photograph of Park City resident and U.S. Ski Team member, Jeremy Nobis enjoys a day of Spring skiing at park City Ski Area; Park City celebrates Spring with the annual Snow-shine Festival, photo taken between 1991 and ...
Park City Ski Corp. / Lori Adamski Peek
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source