Results 171 to 180 of about 2,534,884 (308)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Beyond first-line biologic therapy: does treatment sequence matter in ulcerative colitis? [PDF]

Intest Res
Park YE.
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Author Correction: In vivo mitochondrial base editing restores genotype and visual function in a mouse model of LHON. [PDF]

Nat Commun
Kim S, Kim J, Cha S, Ju S, Lim CJ, Hong S, Bae J, Oh Y, Jung S, Kim SP, Shin HS, Yoon JH, Park J, Ryou S, Lim SY, Lee SB, Choi SH, Park SJ, Choi CG, Choi M, Kim LK, Park J, Lee S, Seo KY, Seong JK, Kim K, Kim JS, Lee H.   +27 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Reading human physiology through adverse drug events. [PDF]

Korean J Physiol Pharmacol
Yang BR, Park SM.
europepmc   +1 more source

Isle Royale National Park transportation study [PDF]

P13PG00312VM04Isle Royale National Park is a remote archipelago located in western Lake Superior, fourteen miles from the closest mainland and 60miles from the park\u2019s headquarters in Houghton, MI.
Bettisworth, Caitlin, Fisher, Frances, Lamoureux, Katie, Carter, Peter, Mannheim, Daniel, Pray, Bob, John A. Volpe National Transportation Systems Center (U.S.)   +6 more
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Park Proximity and Emergency Department Visit Rates for Asthma and Acute Myocardial Infarction in Los Angeles County: A Cross-Sectional Ecological Study. [PDF]

Cureus
Fong JN.
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source