Results 121 to 130 of about 1,650,645 (209)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
, 1991 Black and white photograph of Park City resident and U.S. Ski Team member, Jeremy Nobis enjoys a day of Spring skiing at park City Ski Area; Park City celebrates Spring with the annual Snow-shine Festival, photo taken between 1991 and ...
Park City Ski Corp. / Lori Adamski Peek
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Child safety in parks' playgrounds (a case study in Tehran’s sub-district parks)
Salāmat-i kār-i Īrān, 2010 Background and aimsSafety is a complex concept and multidisciplinary science which is included some difference areas from industrial sectors to urban public arenas.
A.H. Mirlouhi Falavarjani +3 more
doaj
Exterior of the New Park Hotel; front facade of 3-story brick building at 573 Main St. viewed from slightly downhill, looking southwest. Fence at right with a few houses on Park Ave. & Woodside behind.
Jenkins, J.E.
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Rainier National Park in the heart of the great Northwest
, 1936 Travel brochure describing the attractions and facilities at Mount Rainier National Park. Includes travel routes, rates and time schedules for railroads and the Mount Rainier Park Company auto-stages, rates for the Paradise Inn and the National Park Inn ...
Rainier National Park Company
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
By-laws of the Appalachian National Park Association
, 2015 This item includes two drafts of a 5-page document that outlines the by-laws of the Appalachian National Park Association. The original by-laws proposed that the organization be named the “Southern National Park Association” but, by the time it was ...
Gilmer, Robert D., 1858-1925; Lawrence, Thomas; Wittkowsky, Samuel, 1835-1911; Hays, J. F.; Gwyn, Walter B., 1853-1911;
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source